Results 81 to 90 of about 2,613 (292)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A Simplified Numerical Method for the Design and Analysis of FPSO Platform Brackets Subjected to Operational Conditions

Journal of Marine Science and Engineering, 2020
The present work develops a simplified computational methodology to predict brackets’ mechanical behavior to support mooring systems’ fairleads under maximum environmental loads.
Kauê L. Martins, Vinícius T. Pinto, Cristiano Fragassa, Mauro V. Real, Luiz A. O. Rocha, Liércio A. Isoldi, Elizaldo D. dos Santos   +6 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Constant depth microfluidic networks based on a generalised Murray’s law for Newtonian and power-law fluids [PDF]

, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014), Barber, RW, Emerson, DR, Oliveira, MSN, Zografos, K   +4 more
core  

A design rule for constant depth microfluidic networks for power-law fluids [PDF]

, 2015
A biomimetic design rule is proposed for generating bifurcating microfluidic channel networks of rectangular cross section for power-law and Newtonian fluids.
Barber, Robert W., Emerson, David R., Oliveira, Mónica S. N., Zografos, Konstantinos   +3 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Design improvement of circular molten carbonate fuel cell stack through CFD Analysis [PDF]

, 2011
Molten carbonate fuel cell (MCFC) is a promising technology for distributed power generation. The core of an MCFC power generation unit is the stack, where various fuel cells are connected together in series and parallel in order to obtain the desired ...
Adriano Sciacovelli, Arato, Bejan, Bird, Bockris, Bosio, Brouwer, Chan, Fermeglia, Fuller, Gundermann, He, Heidebrecht, Jewulski, Koh, Koh, Krishna, Li, Mangold, Marra, Okada, Pfafferodt, Reid, Sciacovelli, Vittorio Verda, Wijayasinghe, Wilemski, Yoshiba, Yoshikawa, Yu, Yuan, Zhou   +31 more
core   +4 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Design Construction Networks

Ardeth, 2018
This visual essay diagrams a global design construction network that connects architects to migrant construction workers in a direct line. A hypothetical stadium construction site lies in the center; one side maps the movement of a steel truss from design to fabrication to a building site; the other side charts the path of migrant workers as they ...
Kadambari Baxi, Jordan Carver, Laura Diamond Dixit, Lindsey Lee, Tiffany Rattray, Mabel O. Wilson   +5 more
openaire   +3 more sources

Rethinking evolution, entropy and economics: A triadic conceptual framework for the maximum entropy principle as applied to the growth of knowledge [PDF]

Recently, the maximum entropy principle has been applied to explain the evolution of complex non-equilibrium systems, such as the Earth system. I argue that it can also be fruitfully deployed to reconsider the classical treatment of entropy in economics ...
Herrmann-Pillath, Carsten
core