Results 111 to 120 of about 1,839 (290)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Thermodynamics 2.0: Bridging the natural and social sciences. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Poudel R, McGowan J, Georgiev GY, Haven E, Gunes U, Zhang H.   +5 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Engineering Flow and Design [PDF]

, 2015
The importance of design in natural and engineered flow systems is undisputed. It is not only essential to life, but also plays a crucial role in our technological world.
Miguel, A. F., Rocha, Luiz, Öchsner, Andreas   +2 more
core  

Simultaneous Extrema in the Entropy Production for Steady-State Fluid Flow in Parallel Pipes

, 2010
Steady-state flow of an incompressible fluid in parallel pipes can simultaneously satisfy two contradictory extremum principles in the entropy production, depending on the flow conditions.
Andresen, Ang, Attard, Attard, Awumah, Bejan, Bejan, Bruers, Christen, Christen, Crooks, Dewar, Dewar, Dewar, Helmholtz, Jaynes, Juretic, Kleidon, Landauer, Main, Martyushev, Martyushev, Martyushev, Meysman, Niven, Niven, Niven, Niven, Nulton, Onsager, Onsager, Onsager, Ozawa, Salamon, Salamon, Schneider, Setiadi, Županovic   +37 more
core   +1 more source

Natural Fractals as Irreversible Disorder: Entropy Approach from Cracks in the Semi Brittle-Ductile Lithosphere and Generalization. [PDF]

Entropy (Basel), 2022
Venegas-Aravena P, Cordaro EG, Laroze D.
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Elaboration d'une structure de collecte des déchets organiques à l'aide de la théorie constructale [PDF]

, 2014
International audienceLa gestion des déchets présente des enjeux économiques et environnementaux majeurs pour nos sociétés, et notamment sur la question des transports.
Al-Maalouf, George, Glaus, Mathias, Hausler, Robert, Laforest, Valérie, Tanguy, Audrey   +4 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Refroidissement d'un volume fini générant de la chaleur : limites de l'approche constructale

, 2010
International audienceLa répartition optimale, à l'aide de la théorie constructale, d'un matériau hautement conducteur à l'intérieur d'un volume fini générant de la chaleur est un véritable paradigme. Pourtant, il est difficile de comparer les structures
Bougeard, Daniel, Harion, Jean-Luc, Marck, Gilles, Nemer, Maroun, Russeil, Serge   +4 more
core   +1 more source