Results 121 to 130 of about 335 (254)
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Effect of Reverting Channels on Heat Transfer Performance of Microchannels with Different Geometries
Journal of Applied Fluid Mechanics, 2017 This study investigated the effect of reverting microchannels inside a heat sink on increase of cooling rate as well as the effect of their different configurations on maximum temperature and pressure drop. Based on the convection heat transfer mechanism,
Mahsa Farzaneh +2 more
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
The Optimal Spacing between Elliptic Tubes Cooled by Free Convection Using Constructal Theory
مجلة النهرين للعلوم الهندسية, 2017 The optimal spacing between elliptic tubes cooled by free convection is studied numerically. A row of isothermal elliptic tubes are installed in a fixed volume and the spacing between them is selected according to the constructal theory (Bejan's theory).
Ahmed Waheed Mustafa, Jaafar Ahmed Zahi
doaj
On the theory and construction of k-clusters [PDF]
The Computer Journal, 1972 openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao +6 more
wiley +1 more source
The Optimal Spacing between Finned Tubes Cooled by Free Convection Using Constructal Theory
مجلة النهرين للعلوم الهندسية, 2017 The optimal spacing between finned tubes cooled by free convection is studied numerically. A row of isothermal finned tubes are installed in a fixed volume and the spacing between them is selected according to the constructal theory (Bejan's theory).
Ahmed Waheed Mustafa, Mays Munir Ismael
doaj
Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan +14 more
wiley +1 more source
Mathematical Model of a Constructal Coanda Effect Nozzle
Journal of Applied Fluid Mechanics, 2016 This paper analyses the ACHEON Coanda effect nozzle for aircraft propulsion, based on the dynamic equilibrium of two jet streams. The ACHEON concept, and, in particular, the HOMER nozzle, which is its main component, are presented, together with the ...
Michele Trancossi +3 more
doaj