Results 101 to 110 of about 5,380,639 (293)

OPTIMIZATION OF CONTAINER TERMINAL FLOWS THROUGH A CONSTRUCTAL APPROACH AND FLUID FLOW ANALOGY

Journal of Industrial Design and Engineering Graphics, 2014
The existing movement for the reduction of environmental impact and improvement of efficiency of processes led to a need for optimizing the transport and logistic chains.
OANCEA Laurentiu
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Constructal theory of social dynamics

, 2007
Combines for the first time theories of general physics and applies them to social sciencesOffers a new way to look at social phenomena as part of natural phenomenaA new domain of application of engineering such as thermodynamic optimization ...
Bejan, Adrian, Merkx, Gilbert W
core  

Numerical Investigation on Natural Convection Heat Transfer of Spherical Cactus-like Bodies Based on Constructal Theory

Applied Sciences
In both nature and engineering, there are many structures similar to spherical cacti with ribs. In this study, we investigated numerically the laminar natural convection heat transfer characteristics of spherical cactus-like bodies.
Mingshi Gao, Chenjia Liao, Hua Lin, Houlei Zhang   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Critical Reassessment of the Hess–Murray Law

Entropy, 2016
The Hess–Murray law is a correlation between the radii of successive branchings in bi/trifurcated vessels in biological tissues. First proposed by the Swiss physiologist and Nobel laureate Walter Rudolf Hess in his 1914 doctoral thesis and published in ...
Enrico Sciubba
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Constructal design of nanofluids

, 2010
We develop a constructal approach that is capable of finding constructal microstructure of nanofluids for constructal system performance. The approach converts the inverse problem of optimizing the microstructure for the best system performance into a ...
Wang, L, Liqiu Wang, Jing Fan, Fan, J
core   +1 more source

Constructal Design of Thermal Systems (Chapter 17)

, 2013
Constructal Theory accounts for the universal phenomenon of generation and evolution of design. Constructal Theory has been used to explain deterministically the generation of shape in flow structures of nature (river basins, lungs, atmospheric ...
Dos Santos E. D., Rocha L. A. O., Letzow M., Garcia F. L., Isoldi L. A., Lorenzini G., Souza J. A., Cunha D. C., Costa J. A. V., BISERNI, CESARE   +9 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source