Results 81 to 90 of about 1,847 (291)

Optimal design of a dual-pressure radial-inflow turbine for S-CO2 cycle based on constructal theory

Results in Engineering
Based on constructal theory, a dual-pressure turbine (DPT) model for supercritical CO2 cycle is established. Seven kinds of losses, such as the nozzle, incidence, passage, windage, tip clearance, trailing and exit velocity losses, are considered in the ...
Chuang Tang, Huijun Feng, Lingen Chen, Shanlin Liu, Yanlin Ge   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Elaboration d'une structure de collecte des déchets organiques à l'aide de la théorie constructale [PDF]

, 2014
International audienceLa gestion des déchets présente des enjeux économiques et environnementaux majeurs pour nos sociétés, et notamment sur la question des transports.
Al-Maalouf, George, Glaus, Mathias, Hausler, Robert, Laforest, Valérie, Tanguy, Audrey   +4 more
core   +1 more source

Biomimetic flow fields for proton exchange membrane fuel cells: A review of design trends [PDF]

, 2020
Bipolar Plate design is one of the most active research fields in Polymer Electrolyte Membrane Fuel Cells (PEMFCs) development. Bipolar Plates are key components for ensuring an appropriate water management within the cell, preventing flooding and ...
Arredondo, C. H., Iranzo Paricio, Jose Alfredo, Kannan, A. M., Rosa Iglesias, Manuel Felipe   +3 more
core  

Design of an innovative off road hybrid vehicle by energy efficiency criteria [PDF]

, 2016
The environmental impact of road transport is significant because it is a major user of energy and the major user of the world's petroleum that is extracted every year.
Pascoa, Jose, Trancossi, Michele, Xisto, Carlos   +2 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Simultaneous Extrema in the Entropy Production for Steady-State Fluid Flow in Parallel Pipes

, 2010
Steady-state flow of an incompressible fluid in parallel pipes can simultaneously satisfy two contradictory extremum principles in the entropy production, depending on the flow conditions.
Andresen, Ang, Attard, Attard, Awumah, Bejan, Bejan, Bruers, Christen, Christen, Crooks, Dewar, Dewar, Dewar, Helmholtz, Jaynes, Juretic, Kleidon, Landauer, Main, Martyushev, Martyushev, Martyushev, Meysman, Niven, Niven, Niven, Niven, Nulton, Onsager, Onsager, Onsager, Ozawa, Salamon, Salamon, Schneider, Setiadi, Županovic   +37 more
core   +1 more source

Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta [PDF]

, 2014
PURPOSE: The objectives are: (i) assess the development of the impedance of some arteries during the first decades of life; (ii) determine the influence of pulse rate in arterial impedance; (iii) compare the structure of some arterial segments with ...
Silva, Carla
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source