Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Constructal Design of an Entropic Wall With Circulating Water Inside [PDF]
, 2016 An entropic wall with circulating water inside could be a solution for acclimatizing a new building with high-energy efficiency and high levels of internal comfort.
Madonia, Mauro +5 more
core +1 more source
Optimal design of a dual-pressure radial-inflow turbine for S-CO2 cycle based on constructal theory
Results in EngineeringBased on constructal theory, a dual-pressure turbine (DPT) model for supercritical CO2 cycle is established. Seven kinds of losses, such as the nozzle, incidence, passage, windage, tip clearance, trailing and exit velocity losses, are considered in the ...
Chuang Tang +4 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Bejan’s Constructal Theory of Shape and Structure [PDF]
, 2004 Introduction; Chapter 1. River Basins: Geomorphology and DynamicsChapter 2. Tree-Shaped Flow Structures for Human-Scale and Small-Scales Applications; Chapter 3. Dendritic Growth: Classical Models and Constructal Analysis; Chapter 4.
Miguel, A, F.
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Economic Optimization of Shell and Tube Heat Exchanger Based on Constructal Theory
, 2010 In this paper, the new approach of Constructal theory has been employed to design shell and tube heat exchangers. Constructal theory is a new method for optimal design in engineering applications.
Abazar Vahdat Azad, Majid Amidpour
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Constructal theory and flow architectures in living systems [PDF]
, 2006 We apply Constructal theory to the study of the flow structure of the human respiratory tree. We show that the flow architecture that would perform oxygenation of the blood and removal of carbon dioxide best, i. e.
Ferreira Miguel +3 more
core +1 more source