Results 91 to 100 of about 5,380,639 (293)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
DEFINITION OF TIME: FROM THE SECOND TO CONSTRUCTAL LAW [PDF]
One of the open problems in Physics is the analytical definition of time. This paper addresses a possible answer to this topic by proposing an analytical definition of time obtained by the Second Law of Thermodynamics and the Constructal Law ...
Grisolia, G., Lucia, U.
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2019 This work presents a constructal timeline on the webpage umitgunes.net/timeline, which shows the evolution of constructal theory from 1996 to today. All of the most important publications and all conferences in the constructal realm, as well as the total
GÜNEŞ, Ümit, ŞAHİN, Bahri
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Inaccessibility in constructive set theory and type theory
Annals of Pure and Applied Logic, 1998 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Michael Rathjen +2 more
openaire +2 more sources
GEOMETRIC OPTIMIZATION OF “+”-SHAPED CAVITY USING CONSTRUCTAL THEORY [PDF]
, 2017 In this work it is applied the Constructal Theory for the study of the geometry of an “+”-shaped isothermal cavity inserted in a conductive solid body. Main goal is to minimize the maximum temperature in the solid.
Souza, J. A. +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Constructal Law and Thermoeconomic Optimization
, 2017 The paper introduces the concept of Thermoeconomic Environment and discusses how the Constructal Theory can be applied to the productive structure of an energy system.
CASISI M., REINI M.
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Design with Constructal Theory: Steam Generators, Turbines and Heat Exchangers
, 2010 This dissertation shows that the architecture of steam generators, steam turbines and heat exchangers for power plants can be predicted on the basis of the constructal law.
Kim, Yong Sung
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