Results 111 to 120 of about 1,847 (291)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Branching in fluidic networks with permeable walls: an extension of Hess-Murray’s law [PDF]

, 2017
The branching of fluidic networks becomes a subject of great interest due to its importance in understanding the behavior of branching networks in biology (cardiovascular and bronchial systems, river basins, the structure of plants and trees, etc..), as ...
Miguel, A. F., Pepe, Vinícius R., Rocha, Luiz A. O.   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Constructal Design and Friction Stir Processing Synergy: Towards Next-Generation High-Efficiency Heat Sinks

Applied Sciences
The continuous increase in electronic power densities demands thermal management solutions that surpass the conventional heat sink designs. This study introduces a synergistic approach that combines constructal design principles with Friction Stir ...
Joel de Jesus, Miguel Panão, Ricardo Branco   +2 more
doaj   +1 more source

Thermodynamics 2.0: Bridging the natural and social sciences. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Poudel R, McGowan J, Georgiev GY, Haven E, Gunes U, Zhang H.   +5 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Natural Fractals as Irreversible Disorder: Entropy Approach from Cracks in the Semi Brittle-Ductile Lithosphere and Generalization. [PDF]

Entropy (Basel), 2022
Venegas-Aravena P, Cordaro EG, Laroze D.
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Otimização de design do duto ramificado em forma de T com escoamento de fluido newtoniano e paredes impermeáveis [PDF]

, 2018
Este artigo apresenta os resultados de escoamentos em dutos em forma de “T”. O problema consiste em encontrar as resistências ao escoamento em estruturas tridimensionais (3D) cujos sistemas têm diferentes relações homotética entre tamanhos (diâmetros e ...
Miguel, A. F., Pepe, V. R., Rocha, L. A. O., Zinani, F. S. F.   +3 more
core