Results 111 to 120 of about 5,380,639 (293)

SHAPES AND HEAT TRANSFER IN CANCER: THE CONSTRUCTAL RESONANCE [PDF]

, 2019
Any cell process requires energy, so a control of the energy conversion in the cell can represent a way to control the cell processes. Cells regulate their metabolisms by fluxes of energy and mass (ions included). The Constructal law is the thermodynamic
Grisolia G., Lucia U.
core  

ICMM2004 -xxxx CONSTRUCTAL NETWORKS FOR EFFICIENT COOLING/HEATING [PDF]

, 2020
Channel networks designed with constructal theory are compared. The efficiency of the networks when used for cooling a uniformly heated surface is compared.
Bernard Thonon, Jean Antoine Gruss, Fredrik Lundell   +2 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Pseudo-constructal theory for shape optimization of mechanical structures

, 2008
International audienceThis work gives some applications of a pseudo-constructal technique for shape optimization of mechanical structures. In the pseudo-constructal theory developed in this paper, the main objective of optimization is only the ...
Marcelin, Jean-Luc
core  

Constructal theory of pedestrian dynamics

, 2009
The standard benefit of modeling pedestrian streams is the ability to quantify and understand flow patterns, which can be helpful to avoid some potentially dangerous situations. Here we show that the most basic features of pedestrian dynamics can be put on
Miguel, A. F.
core   +1 more source

Numerical Optimization of an Array of Triangular Microchannels using Constructal Theory

Journal of Applied Fluid Mechanics, 2019
In the present study, an arrangement of triangular microchannels with different contact angles is analyzed and optimized following the guidelines provided by the constructal theory to reach to the maximum heat removal rate.
M. Mardani, M. R. Salimpour
doaj   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Constructal allocation of nanoparticles in nanofluids

, 2010
We perform a constructal design of heat conduction in a blade-configured disk-shaped domain with uniform heat generation and periphery heat-sink by introducing a transition line from two-path conduction to one-path conduction in the domain.
Bai, C, Wang, L
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Thermodynamics 2.0: Bridging the natural and social sciences. [PDF]

Philos Trans A Math Phys Eng Sci, 2023
Poudel R, McGowan J, Georgiev GY, Haven E, Gunes U, Zhang H.   +5 more
europepmc   +1 more source