Results 81 to 90 of about 8,837,157 (332)
Structure and adaptation of arteries to pulsatile flow - The case of the ascending aorta [PDF]
, 2014 PURPOSE: The objectives are: (i) assess the development of the impedance of some arteries during the first decades of life; (ii) determine the influence of pulse rate in arterial impedance; (iii) compare the structure of some arterial segments with ...
Silva, Carla
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Optimal design of a dual-pressure radial-inflow turbine for S-CO2 cycle based on constructal theory
Results in EngineeringBased on constructal theory, a dual-pressure turbine (DPT) model for supercritical CO2 cycle is established. Seven kinds of losses, such as the nozzle, incidence, passage, windage, tip clearance, trailing and exit velocity losses, are considered in the ...
Chuang Tang +4 more
doaj +1 more source
“Recent Advances in Energy Research” [PDF]
, 2008 The worldwide scarcity of fossil fuels regarding primary energy demand together with growing environmental concerns have raised new challenges to the world economy, and led to changes in the energy paradigm.
Miguel, A. F., Reis, A. Heitor
core
Design of an innovative off road hybrid vehicle by energy efficiency criteria [PDF]
, 2016 The environmental impact of road transport is significant because it is a major user of energy and the major user of the world's petroleum that is extracted every year.
Pascoa, Jose +2 more
core +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Coal and fuel burning effects on the atmosphere as mediated by the atmospheric electric field and galactic cosmic rays flux [PDF]
, 2009 : Emissions into the atmosphere of Greenhouse Gases (GHGs) and particulate matter resulting from fossil fuel burning are considered to be the main anthropogenic forcing on the global climate.
Reis, A. Heitor, Serrano, Claudia
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source