Results 51 to 60 of about 2,179,886 (275)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Productive Action

Культурно-историческая психология, 2019
The key issue of the paper is the question of the means of Existence of human action and, therefore, of the actor himself/herself. The concept of ‘action’ refers to different types of action performance: effective action, play action, learning action and,
Elkonin B.D.
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A New Sigma Model Action for the Four-Dimensional Green-Schwarz Heterotic Superstring

, 1993
The sigma model action described in this paper differs in four important features from the usual sigma model action for the four-dimensional Green-Schwarz heterotic superstring in a massless background.
Bergshoeff, Berkovits, Berkovits, Berkovits, Berkovits, Callan, Carlip, de Azcarraga, Delduc, Delduc, Dine, Gates, Gates, Gates, Gates, Gates, Gilbert, Grisaru, Grisaru, Ivanov, Kraemmer, Mukhi, Nathan Berkovits, Ogievetsky, Penrose, Sorokin, Tonin, Witten   +27 more
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Spinor and Twistor Formulations of Tensionless Bosonic Strings in Four Dimensions

, 2010
Spinor and twistor formulations of tensionless bosonic strings in 4-dimensional Minkowski space are constructed. We begin with a first-order action that is equivalent to the Nambu-Goto action in the tensionful case and that leads to a spinorial action in
Deguchi, Shinichi, Egami, Takeshi, Note, Jun-ichi   +2 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Cognitive spaces: Expanding participation framework by looking at signed language interpreters’ discourse and conceptual blending

Translation and Interpreting : the International Journal of Translation and Interpreting Research, 2014
We know from previous research (Wadenjso, 1998; Metzger, 1999; Roy, 2000) that interpreters are active participants within the interpreting event. We know that interpreters interact with the participants, and discourse by negotiating turn-taking, and ...
Julie White Armstrong
doaj  

3D supersymmetric nonlinear multiple D0-brane action and 4D counterpart of multiple M-wave system

Journal of High Energy Physics, 2022
Found is the complete nonlinear action of multiple D0-brane system (mD0) in three dimensional type II superspace which is invariant under rigid D = 3 N $$ \mathcal{N} $$ = 2 spacetime supersymmetry and under local worldline supersymmetry generalizing the
Igor Bandos, Unai D. M. Sarraga
doaj   +1 more source