Results 81 to 90 of about 2,012,270 (353)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Comprehensive evaluation of low-temperature properties of PPA/CR/SBS composite modified asphalt binder and its mixtures

open access: yesResults in Engineering
Asphalt pavement in cold regions often suffer from serious cracking issues, which will greatly shorten its service life. Composite modification employing polyphosphoric acid (PPA), crumb rubber (CR), and styrene-butadiene-styrene block copolymer (SBS ...
Fucheng Guo   +8 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

The impact of training and development on career advancement of professional women in the UK construction industry [PDF]

open access: yes
The redressing the gender imbalance in the UK construction industry has been emphasised on numerous occasions and many researchers have identified that women can contribute in an immense way towards the construction industry development.
Amaratunga, Dilanthi, Fernando, G.
core  

The social protection of rural workers in the construction industry in urban China [PDF]

open access: yes, 2006
The construction industry is important for Chinese rural to urban migrants. Over 90% of urban construction workers are rural migrants, and over a third of all rural migrants work in construction.
Li, Bingqin, Peng, Huamin
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Immersive learning behavior analysis based on UWB positioning and innovative education mode

open access: yesDiscover Applied Sciences
The rapid development of intelligent education and human-computer interaction has given rise to the demand for immersive learning, which has raised higher requirements for indoor spatial positioning accuracy and learning behavior recognition ability.
Xiangcui Huang   +3 more
doaj   +1 more source

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