Results 131 to 140 of about 3,483,321 (306)

Industry-driven innovative system development for the construction industry: The DIVERCITY project [PDF]

open access: yes, 2004
Collaborative working has become possible using the innovative integrated systems in construction as many activities are performed globally with stakeholders situated in various locations.
Aouad, GF, Arayici, Y
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Drawing the line: balancing the spatial requirements of customer and contractor in occupied refurbishment [PDF]

open access: yes, 2003
In planning the refurbishment of railway stations the spatial needs of the contractor and ofthe ongoing business stakeholders have to be balanced.
Kelsey, JM
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Management of contractor's claim in Turnkey projects according to FIDIC under termination and dissolution of contract [PDF]

open access: yesمهندسی و مدیریت ساخت, 2019
Generally, increasing complexity of the structural stages of the contracts and contracting conditions as well as inconvenient conditions of projects including Meteorological, political, and leads to intensification of disputes, claims and litigation ...
Amir Momeni, Mohsen Heidari
doaj  

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