Results 61 to 70 of about 9,030 (293)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Constructionism as a media paradigm [PDF]

CM. Communication and Media, 2018
Research of the nature of mass communication by using different theoretical approaches has gone a long way since its perception as a transmission of symbolic content (whose aim is to create certain effect used for confirming or questioning social order ...
Marković Branko
doaj  

Artifacts, Visual Modeling and Constructionism: To Look More Closely, to Watch What Happens

Problemos, 2018
[full article, abstract in English; abstract in Lithuanian] Constructionists operationalize a powerful notion they share with constructivists: individual learning is facilitated by building models of specific ideas, concepts, methods, objects ...
James E. Clayson
doaj   +1 more source

Towards a realist social constructionism [PDF]

, 2012
Towards a realist social constructionism Social constructionism has often been seen as incompatible with realist approaches to the socialworld.
Dave Elder-Vass (1252800)
core  

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Social constructionism turned into human service work

, 2015
Studies of applied constructionism are opportunities for scholars to explore how social constructionism is a resource used by claims-makers in describing and justifying their orientations to professional practice.
Järvinen, Margaretha, Miller, Gale
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Videogame Construction by Engineering Students for Understanding Modelling Processes: The Case of Simulating Water Behaviour

Informatics in Education, 2015
We present some results of an ongoing research project where university engineering students were asked to construct videogames involving the use of physical systems models.
Angel PRETELÍN-RICÁRDEZ, Ana Isabel SACRISTÁN   +1 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Living with generative AI: considering constructionist approaches to learning and methodological implications of process ontologies

Frontiers in Education
The growing presence of generative artificial intelligence (GenAI) in educational practice raises questions about how learners and educators live with AI and reshapes questions about how learning unfolds across contemporary learning environments ...
Jimin Lee, Nancy Budwig
doaj   +1 more source