Results 51 to 60 of about 1,147,409 (263)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Dialect areas and contact dialectology
, 2023 Spatial variation of language has been researched qualitatively and quantitatively for at least 150 years by different sub-disciplines of linguistics, each defining differently what dialects and dialect areas are. Linguists agree, however, that the concept of dialect is vague and the extent of a dialect is fuzzy.
Jeszenszky, Péter +2 more
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Cohesive Crack with Partially Contacting Faces in Section of the Road Covering
Механика машин, механизмов и материалов, 2012 The case of a longitudinal crack with interfacial bonds in section of a road covering with partially contacting faces is considered. It is considered, that under action of external loading (cave-in of a wheel in a rough surface of a covering) in a zone ...
Sh.G. Hasanov
doaj
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Contact mechanics with adhesion: Interfacial separation and contact area [PDF]
EPL (Europhysics Letters), 2008 We study the adhesive contact between elastic solids with randomly rough, self affine fractal surfaces. We present molecular dynamics (MD) simulation results for the interfacial stress distribution and the wall-wall separation. We compare the MD results for the relative contact area and the average interfacial separation, with the prediction of the ...
Yang, C. +3 more
openaire +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Dynamic Behaviors of Contact Surfaces in the Sliding Friction of a Soft Material
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2007 It is known that detachment waves are generated on the surface of a soft material when it is slid on a hard surface under certain conditions. In the present study, the variation in the contact area that arises when a plate of a cross-linked polymer, poly-
Satoru MAEGAWA, Ken NAKANO
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source