Results 41 to 50 of about 432,503 (265)
Purpose: Electroanatomical mapping (EAM) could increase cardiac magnetic resonance imaging (CMR) sensitivity in detecting ventricular scar. Possible bias may be scar over-estimation due to inadequate tissue contact.
Luigi Sciarra +15 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Sliding Mode Contact Force Control of n-Dof Robotics by Force Estimation
Control of the force exerted on an object is important for boosting system performance in robotics manipulators. Any undesired applied force may leave remarkable effects on the system, with the potential to damage the object.
Majid Namnabat +2 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Objective Contact force is a crucial aspect of comprehensive detection in the rail transit PC (pantograph-catenary) system and serves as an important evaluation factor of PC system performance.
YANG Jinsong +5 more
doaj +1 more source
In the tritium breeding blanket of nuclear fusion reactors, the heat transfer behavior and thermal-mechanical response of the tritium breeder pebble bed are affected by the inner packing structure, which is crucial for the design and optimization of a ...
Baoping Gong +5 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Aiming at the three-body contact problem of mechanical rough surface containing wet coal dust interface, the three-body contact model of rough surface containing wet coal dust interface is constructed by comprehensively considering the contact ...
Xinwei Yang +4 more
doaj +1 more source
Precisely fitting the bottom sticker of the wine box base to the base model with glue is an important process of the wine box base production line. The influence of joint clearance in the assembly robot on the assembly precision of wine box bases is ...
Yuan Wang +4 more
doaj +1 more source
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source

