Results 61 to 70 of about 3,105,890 (299)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Identification of force chains in wet coal dust layer and the effect of porosity on three-body contact stiffness

Scientific Reports
Aiming at the three-body contact problem of mechanical rough surface containing wet coal dust interface, the three-body contact model of rough surface containing wet coal dust interface is constructed by comprehensively considering the contact ...
Xinwei Yang, Dongxuan Wu, Yangxi Bai, Hongyue Chen, Xin Wang   +4 more
doaj   +1 more source

Research on Multi-Body Collision Dynamics of Ball Cage Flexible Drill Pipe Considering Borehole Curvature

Machines, 2023
A ball cage flexible drill pipe is a new type of ultra-short-radius drilling tool, which consists of multiple flexible joints hinged together. During the drilling process, the flexible members will come into contact and wear, which reduces the efficiency
Xiuxing Zhu, Yingpeng Xu, Chenyang Mao, Weixia Zhou, Yuanbo Xia, Guigen Ye, Bo Zhou   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A New Contact Force Estimation Method for Heavy Robots Without Force Sensors by Combining CNN-GRU and Force Transformation

Technologies
In response to the safety control requirements of heavy robot operations, to address the problems of cumbersome, time-consuming, poor accuracy and low real-time performance in robot end contact force estimation without force sensors by using traditional ...
Peizhang Wu, Hui Dong, Pengfei Li, Yifei Bao, Wei Dong, Lining Sun   +5 more
doaj   +1 more source

A Finite Element-Based Elastic-Plastic Model for the Contact of Rough Surfaces

Modelling and Simulation in Engineering, 2011
Three-dimensional elastic-plastic contact of two nominally flat rough surfaces is considered. Equations governing the shoulder-shoulder contact of asperities are derived based on the asperity constitutive relations from a finite element model of the ...
Ali Sepehri, Kambiz Farhang
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Wheel–Rail Contact Force for a Heavy-Load Train Can Be Measured Using a Collaborative Calibration Algorithm

Information
The wheel–rail contact force is a crucial indicator for ensuring the secure operation of a heavy-load train. However, obtaining the real-time wheel–rail contact force of a heavy-load train is a challenging task as, due to safety considerations, it is not
Tianning Wen, Jing He, Changfan Zhang, Jia He   +3 more
doaj   +1 more source

Sufficient Conditions Used in Admittance Selection for Planar Force-guided Assembly [PDF]

, 2002
Admittance control approaches show significant promise in providing reliable force-guided assembly. An important issue in the development of these approaches is the specification of an appropriate admittance control law.
Huang, Shuguang, Schimmels, Joseph M.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source