Results 41 to 50 of about 2,409,835 (286)

Mechanics Analysis of Rough Surface Based on Shoulder-Shoulder Contact

Applied Sciences, 2021
Proper methods and models for mechanical analysis of rough surface can improve the theory of surface contact. When the topography parameters of two rough surfaces are similar, the contact should be considered shoulder-shoulder rather than top-top.
Qiuping Yu, Jianjun Sun, Zhengbo Ji
doaj   +1 more source

Mechanisms of Allergic Contact Dermatitis

, 2001
Allergenicity depends on several factors determined by the very physicochemical nature of the molecules themselves, i.e., their capacity to penetrate the horny layer, lipophilicity, and chemical reactivity. The sensitizing property of the majority of contact allergens could be predicted from these characteristics (Patlewicz et al., Contact Dermatitis ...
Rustemeyer, Thomas, Van Hoogstraten, Ingrid M.W., Von Blomberg, B. Mary E., Scheper, Rik J.   +3 more
openaire   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A novel approach to modelling and simulating the contact behaviour between a human hand model and a deformable object [PDF]

, 2012
A deeper understanding of biomechanical behaviour of human hands becomes fundamental for any human hand-operated Q2 activities. The integration of biomechanical knowledge of human hands into product design process starts to play an increasingly important
Chamoret, Dominique, Gomes, S, Peyraut, François, Yan, Xiu-Tian, D. Chamoret, F. Peyraut, Z.-Q. Feng, Feng, Zhi-Qiang, Chamoret, D, Peyraut, F, Gomes,, Samuel, X.-T. Yan, Roth, S, S. Roth, Roth, Sébastien, S. Gomes, Yan, Xiu, Feng, Z.-Q   +17 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

First approach to unilateral transfemoral amputees' contact mechanics

Dyna, 2017
The stresses in the hip area have great importance because of their relationship to the health of the joint. Finite element models can predict contact between cartilages, however, contact patterns in unilateral transfemoral amputees have not yet been ...
Isabela Mariaka Flórez, Juan Fernando Ramírez Patiño   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Energy and Force Stepping Integrators in Lagrangian Mechanics [PDF]

, 2011
The overarching goal of this thesis is to develop new numerical time integration schemes for Lagrangian mechanics that better cope with the challenges of understanding the dynamic behavior of materials.
Gonzalez, Marcial
core   +1 more source