Results 51 to 60 of about 739,596 (278)
Tykhonov well-posedness of fixed point problems in contact mechanics
Fixed Point Theory and Algorithms for Sciences and Engineering, 2022 We consider a fixed point problem S u = u $\mathcal {S}u=u$ where S : C ( R + ; X ) → C ( R + ; X ) ${\mathcal {S}:C(\mathbb{R}_{+};X)\to C(\mathbb{R}_{+};X)}$ is an almost history-dependent operator.
Mircea Sofonea
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Journal of the Mechanical Behavior of Materials, 2019 Adhesion between bodies is strongly influenced by surface roughness. In this note, we try to clarify how the statistical properties of the contacting surfaces affect the adhesion under the assumption of long-range adhesive interactions.
Violano Guido +2 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
A nonlocal contact formulation for confined granular systems
, 2011 We present a nonlocal formulation of contact mechanics that accounts for the interplay of deformations due to multiple contact forces acting on a single particle.
Cuitino, Alberto, Gonzalez, Marcial
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AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
IEEE Access, 2019 Loss of meniscal function due to symptomatic meniscal tears or meniscectomy leads to biomechanical instability and articular cartilage degeneration. Synthetic meniscal implants ought to ideally restore normal joint contact mechanics and thus forfending ...
Duraisamy Shriram +3 more
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Contact mechanics and friction: Role of adhesion
FrictionThis paper presents an overview of the role of adhesion in various tribological phenomena. We discuss (1) adhesion and adhesive hysteresis in rough contacts, (2) adhesive contribution to dry friction, (3) properties of adhesive contacts under tangential ...
Valentin L. Popov +2 more
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Leak-rate of seals: effective medium theory and comparison with experiment
, 2009 Seals are extremely useful devices to prevent fluid leakage. We present an effective medium theory of the leak-rate of rubber seals, which is based on a recently developed contact mechanics theory.
Lorenz, B., Persson, B. N. J.
core +1 more source