Results 71 to 80 of about 739,596 (278)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Elastic and Elastoplastic Contact Mechanics of Concentrated Coated Contacts

Lubricants
Machines operate under increasingly harsher contact conditions, causing significant wear and contact fatigue. Sub-surface stresses are responsible for the premature contact fatigue of rolling element bearings, meshing gears, and cam–follower pairs ...
Patricia M. Johns-Rahnejat, Nader Dolatabadi, Homer Rahnejat   +2 more
doaj   +1 more source

On the validity of the method of reduction of dimensionality: area of contact, average interfacial separation and contact stiffness

, 2013
It has recently been suggested that many contact mechanics problems between solids can be accurately studied by mapping the problem on an effective one dimensional (1D) elastic foundation model. Using this 1D mapping we calculate the contact area and the
Lyashenko, I. A., Pastewka, Lars, Persson, Bo N. J.   +2 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Elastic modulus of hyaluronic acid hydrogels by compression testing

Journal of Materials Science: Materials in Medicine
Hyaluronic acid was crosslinked using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide to form hydrogels with low elastic modulus.
Rachel Lee, Emily K. Hall, Bassam A. Aljohani, Jake McClements, Marloes Peeters, Mark Geoghegan   +5 more
doaj   +1 more source

Biomechanical Consequences of Lateral Meniscal Posterior Root Avulsions

Orthopaedic Journal of Sports Medicine, 2015
Objectives: Lateral meniscal posterior root avulsions are commonly found with anterior cruciate ligament (ACL) tears. The purpose of this study was to investigate the biomechanical effects of lateral meniscal posterior root avulsions with and without ...
Andrew G. Geeslin MD, David Marc Civitarese B.A., Travis L. Turnbull PhD, Grant Dornan MSc, Fernando Fuso MD, Robert F. LaPrade MD, PhD   +5 more
doaj   +1 more source

Contact mechanics of soft granular materials with capillary interaction [PDF]

EPJ Web of Conferences
Engineering applications of soft granular materials require accurate characterisation of their mechanical properties (e.g., Young’s modulus). However, the formation of liquid bridges between the high-water-content surface and substrate introduces ...
Zhao Jiayin, Zhong Haiyi, Gan Yixian
doaj   +1 more source

Mechanism of Contact between a Droplet and an Atomically Smooth Substrate

, 2017
When a droplet gently lands on an atomically smooth substrate, it will most likely contact the underlying surface in about 0.1 s. However, theoretical estimation from fluid mechanics predicts a contact time of 10 to 100 s.
Liu, Yuan, Lo, Hau Yung, Xu, Lei
core   +2 more sources

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source