Results 61 to 70 of about 739,596 (278)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

To the 60th Anniversary of Professor Alexander Vladimirovich Manzhirov

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2017
On May, 24, 2017 the 60th jubilee of Prof. A.V. Manzhirov was celebrated at Ishlinsky Institute for Problems in Mechanics of the Russian Academy of Sciences. Prof. A.V.
Yu N Radayev, V P Padchenko
doaj   +1 more source

Duality and Anholonomy in Quantum Mechanics of 1D Contact Interactions

, 2000
We study systems with parity invariant contact interactions in one dimension. The model analyzed is the simplest nontrivial one --- a quantum wire with a point defect --- and yet is shown to exhibit exotic phenomena, such as strong vs weak coupling ...
Albeverio S., Albeverio S., Avron J. E., Cheon T., Cheon T., Exner P., Fülöp T., Gesztesy F., Gesztesy F., Jackiw R., Junker G., Kostrykin V., Manoharan H. C., Šeba P.   +13 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Experimental study of sand grains behavior at their contacts with force- and displacement-controlled sliding tests

Underground Space, 2017
Discrete element modeling requires the proper quantification of the behavior of grains at their contacts including the normal force – displacement and tangential force – displacement relationships to be used as input for contact modeling purposes.
K. Senetakis, C.S. Sandeep
doaj   +1 more source

A three-dimensional fractal model of the normal contact characteristics of two contacting rough surfaces

AIP Advances, 2021
According to the common characteristics of elastic mechanics and plastic mechanics expressions, a new model of asperity elastic–plastic contact is developed.
Guosheng Lan, Wan Sun, Xueliang Zhang, Yonghui Chen, Wenbing Tan, Xiang Li   +5 more
doaj   +1 more source

General contact mechanics theory for randomly rough surfaces with application to rubber friction

, 2015
We generalize the Persson contact mechanics and rubber friction theory to the case where both surfaces have surface roughness. The solids can be rigid, elastic or viscoelastic, and can be homogeneous or layered.
Persson, Bo N. J., Scaraggi, Michele
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source