Results 81 to 90 of about 35,737,382 (164)

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice

Autism Research, Volume 19, Issue 7, July 2026.
ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown.
Krisztina Sáfár, Vivien Szendi, Paulina Hoppa, Yutong Wang, Fanni Á. Seres, Szilvia Bartók, Tyler Teadora, Lei Shi, Árpád Dobolyi, Gina Puska, István Adorján   +10 more
wiley   +1 more source

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

British Journal of Pharmacology, Volume 183, Issue 13, Page 3723-3742, July 2026.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita   +6 more
wiley   +1 more source

A study of the behaviour and interactions of the novel FERM protein Willin [PDF]

, 2008
Willin is a novel member of the Four-point-one Ezrin Radixin Moesin (FERM) protein superfamily, containing an N-terminal FERM domain most like the Ezrin-Radixin-Moesin (ERM) family but also the closely related protein Merlin.
Herron, Lissa Rocha
core   +2 more sources

Genetic associations of plasma proteomics with dementia subtypes and neuroimaging markers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Dementia is a rising global health challenge. Advances in large‐scale proteomics and genetic databases have enabled high‐throughput screening approaches to uncover novel mechanistic pathways and therapeutic targets. METHODS This study used a
Ahmed M. Salih, Janek Salatzki, Yuhe Wang, Tesfamariam Akilu, Cynthia Maldonado, Masud Husain, Stefan Neubauer, Anya Topiwala, André Altmann, Zahra Raisi‐Estabragh   +9 more
doaj   +1 more source

Contactin-associated protein-like 2 expression in SH-SY5Y cells is upregulated by a FOXP2 mutant with a shortened poly-glutamine tract

Molecular Medicine Reports, 2012
The forkhead box protein P2 (FOXP2) gene encodes an important transcription factor that contains a polyglutamine (poly‑Q) tract and a forkhead DNA binding domain. It has been observed that FOXP2 is associated with speech sound disorder (SSD), and mutations that decrease the length of the poly‑Q tract were identified in the FOXP2 gene of SSD patients ...
Yunjing, Zhao, Xiaoliang, Liu, Hongwei, Sun, Yueping, Wang, Wenzhu, Yang, Hongwei, Ma   +5 more
openaire   +3 more sources

Contactin-associated protein 2 autoantibodies can be associated with multifocal motor-like neuropathy: a case report

Autoantibodies against contactin-associated protein 2 (CASPR2) are usually associated with autoimmune encephalitis and neuromyotonia. Their association with inflammatory neuropathies has been described in case reports albeit all with distal symmetric ...
Schilling, M. (Matthias), Gross, C.C. (Catharina), Beuker, C. (Carolin), Wiendl, H. (Heinz), Schulte-Mecklenbeck, A. (Andreas), Meyer zu Hörste, G. (Gerd), Müller‑Miny, L. (Louisa), Sauer, R. (Raoul), Kovać, S. (Stjepana)   +8 more
core   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Toth, Julia, Wilhelm J. Schwaeble, Christopher Furze, Russell Wallis, Keeble, A. H., Julia Toth, Keeble, Anthony H., Girija, Umakhanth Venkatraman, Wallis, Russell, Mitchell, D. A., Daniel A. Mitchell, Toth, J., Schwaeble, W. J., Schwaeble, Wilhelm J., Anthony H. Keeble, Furze, C., Umakhanth Venkatraman Girija, Furze, Christopher M., Mitchell, Daniel A., Wallis, R., Venkatraman Girija, U.   +20 more
core   +1 more source

Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity

Translational Psychiatry
Maternal anti-Caspr2 (Contactin-associated protein-like 2) antibodies have been associated with increased risk for autism spectrum disorder (ASD). Previous studies have shown that in utero exposure to anti-Caspr2 antibodies results in a phenotype with ...
Julia Su, Rohan Gupta, Scott van Hoof, Jakob Kreye, Harald Prüß, Benjamin Spielman, Lior Brimberg, Bruce T. Volpe, Patricio T. Huerta, Betty Diamond   +9 more
doaj   +1 more source

A rare presentation of CASPR2-associated Morvan syndrome overlapping with GM1-positive AMSAN: a case report

Frontiers in Immunology
BackgroundMorvan syndrome is a rare autoimmune disorder characterized by peripheral nerve hyperexcitability with autonomic and central nervous system involvement, most commonly associated with antibodies against contactin-associated protein-like 2 ...
Yajing Wu, Yajing Wu, Xiaoli Tang, Tianyuan Guan, Jing Xu, Peiyuan Lv, Peiyuan Lv, Yanhong Dong, Yanhong Dong   +8 more
doaj   +1 more source

Genetic variability of FOXP2 and its targets CNTNAP2 and PRNP in frontotemporal dementia: A pilot study in a southern Italian population

Heliyon
The Forkhead box P2 (FOXP2) is an evolutionary conserved transcription factor involved in the maintenance of neuronal networks, implicated in language disorders.
Paolina Crocco, Francesco De Rango, Francesco Bruno, Antonio Malvaso, Raffaele Maletta, Amalia C. Bruni, Giuseppe Passarino, Giuseppina Rose, Serena Dato   +8 more
doaj   +1 more source