Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Delving into EFL teachers' digital literacy and professional identity in the pandemic era: Technological Pedagogical Content Knowledge (TPACK) framework. [PDF]
Heliyon, 2023 Su Y.
europepmc +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Impact of Knowledge Creation and Sharing on Knowledge Use Among Librarians in Federal Universities in Nigeria [PDF]
This paper aims to determine the impact of knowledge creation and sharing on use by librarians in federal universities in Nigeria. The study adopted the survey method of the correlation type, where 518 librarians were surveyed through a close-ended ...
Popoola, Sunday Olanrewaju +1 more
core
From pedagogical content knowledge toward technological pedagogical content knowledge frameworks and their effectiveness in teaching mathematics: A mapping review. [PDF]
F1000Res, 2022 Habiyaremye HT +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Empirical Research on Technological Pedagogical Content Knowledge (TPACK) Framework in Health Professions Education: A Literature Review. [PDF]
Med Sci Educ, 2023 Ait Ali D +5 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
The Development of the Pedagogical Content Knowledge (PCK) Standard for Malaysian ICT Teachers
Journal of ICT in Education, 2019 The main aim of this study is to develop the Pedagogical Content Knowledge (PCK) standard for Malaysian ICT teachers. The researchers used the Delphi method to analyze data elicited from a group of practitioners, namely 245 expert ICT teachers who ...
Sulaiman Sarkawi +5 more
doaj
Findings from the expert-novice paradigm on differential response behavior among multiple-choice items of a pedagogical content knowledge test - implications for test development. [PDF]
Front Psychol, 2023 Lieberei T +3 more
europepmc +1 more source