Results 71 to 80 of about 6,759,339 (303)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Contextual analysis: a multiperspective inquiry into emergence of complex socio-cultural systems [PDF]

open access: yes, 2009
This paper explores the concept of organizations as complex human activity systems, through the perspectives of alternative systemic models. The impact of alternative models on perception of individual and organizational emergence is highlighted.
Bednar, Peter
core  

From Classroom Context to Financial Practice: A Qualitative Study of Contextual Financial Literacy Education and Its Role in Students’ Financial Understanding and Behavior

open access: yesJurnal Kependidikan
This study aims to describe the implementation of contextual-based financial literacy learning and to explore its role in shaping the financial understanding, attitudes, and behaviors of junior high school students at SMP Negeri 10 Palopo.
Muthmainnah, Amriani, Antong, Dedi Aco
doaj   +1 more source

PENGARUH PENGGUNAAN MODUL PEMBELAJARAN KONTEKSTUAL TERHADAP HASIL BELAJAR SISWA KELAS V SEKOLAH DASAR

open access: yesJurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2016
The objective of this study to determine the effect of contextual learning moduls use student achievement of students in grade V in charge of thematic material in SD Muhammadiyah 9 Malang.
Efi Nilasari   +2 more
doaj   +1 more source

AdaLinUCB: Opportunistic Learning for Contextual Bandits [PDF]

open access: yesProceedings of the Twenty-Eighth International Joint Conference on Artificial Intelligence, 2019
In this paper, we propose and study opportunistic contextual bandits - a special case of contextual bandits where the exploration cost varies under different environmental conditions, such as network load or return variation in recommendations. When the exploration cost is low, so is the actual regret of pulling a sub-optimal arm (e.g., trying a ...
Xueying Guo   +2 more
openaire   +4 more sources

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Authentic Assessment as a Catalyst for Student Engagement and Contextual Learning: A Qualitative Study of Classroom Practices in Secondary Education

open access: yesSocial Sciences and Humanities Reviews
Background: Traditional assessment often emphasizes memorization and standardized testing, offering limited insight into students’ ability to apply knowledge in meaningful contexts.
Jelli Anggriana, Maghdahalena Tjalla
doaj   +1 more source

PEMBINAAN MANAJEMEN EKONOMI SYARIAH ANGGOTA KOPERASI WANITA SYARIAH AS SALAM BULUSARI TULUNGAGUNG

open access: yesDinamisia, 2019
Institutionally, the Sharia Cooperatives for Women (Koperasi Wanita Syariah, Ind.) in East Java were established top down based on the Minister of Home Affairs Regulation and the East Java Governor's Decree.
Agus Eko Sujianto
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

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