Results 141 to 147 of about 420 (147)

Advances in contezolid: novel oxazolidinone antibacterial in Gram-positive treatment

Infection
The principal objective of this project was to review and thoroughly examine the chemical characteristics, pharmacological activity, and quantification methods associated with contezolid.The article was based on published and ongoing preclinical and clinical studies on the application of contezolid.
Guan-Xuan-Zi, Zhang, Ting-Ting, Liu, Ai-Xia, Ren, Wen-Xin, Liang, Hong, Yin, Yun, Cai   +5 more
openaire   +2 more sources

Contezolid, a novel oxazolidinone antibiotic, acts as a potential anti-inflammatory agent

The Journal of Antibiotics
Contezolid, a novel oxazolidinone antibiotic, has comparable or superior antibacterial efficacy and safety to linezolid, now widely used for treating multidrug-resistant Gram-positive bacterial infections. Although numerous studies have investigated the immunomodulatory effects of oxazolidinone antibiotics, the immunomodulatory properties of contezolid
Lu Liu, Junsheng Chen, Yajie Deng, Fei Gao, Ting Lin, Zhijun Yang, Daijie Chen, Yu Yin   +7 more
openaire   +2 more sources

Preclinical toxicity evaluation of novel antibacterial contezolid acefosamil in rats and dogs

Journal of Applied Toxicology
AbstractContezolid acefosamil (CZA) is an intravenous prodrug of oxazolidinone antibiotic contezolid (CZD). It is being developed to treat infections due to Gram‐positive bacteria including multidrug‐resistant pathogens, while addressing myelosuppression and neurotoxicity limitations associated with long‐term use of this class of antibiotics.
Wen Wang, Zhengyao Li, Mikhail F. Gordeev, Hong Yuan   +3 more
openaire   +2 more sources

Multicentre evaluation of in vitro activity of contezolid against drug-resistant Staphylococcus and Enterococcus

Journal of Antimicrobial Chemotherapy
Abstract Background To investigate susceptibility to contezolid, a novel oxazolidinone, multicentre surveillance was conducted involving 2449 strains of Staphylococcus and Enterococcus collected from 65 hospitals across China. Methods
Wenhang, Yang, Xue, Li, Jiawei, Chen, Ge, Zhang, Jin, Li, Jingjia, Zhang, Tong, Wang, Wei, Kang, Haotian, Gao, Zhijie, Zhang, Yong, Liu, Yuling, Xiao, Yi, Xie, Jianhong, Zhao, Liyan, Mao, Ziyong, Sun, Gang, Li, Wei, Jia, Guibo, Song, Bin, Shan, Yanhua, Yu, Guizhen, Sun, Yingchun, Xu, Yali, Liu   +23 more
openaire   +2 more sources

Improved Solubility of Contezolid via an O-Acyl Phosphoramidate Prodrug

Synfacts, 2022
openaire   +1 more source

Contezolid. Monoamine oxidase-A (MAO-A) inhibitor, Treatment of acute bacterial skin and skin structure infections

Drugs of the Future, 2020
null Kaul, G., null Dasgupta, A., null Chopra, S.   +2 more
openaire   +1 more source

Contezolid has better safety profile than linezolid

Reactions Weekly
openaire   +1 more source