Results 121 to 130 of about 9,016,160 (399)
Distance education at conventional universities in Germany [PDF]
, 2010 Germany’s educational system has undergone a series of transformations during the last 40 years. In recent years, marked increases in enrolment have occurred.
Kappel, Hans-Henning +2 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Вестник трансплантологии и искусственных органовObjective: organ transplantation is a highly effective and often the only possible definitive treatment for terminal diseases, significantly improving patient survival and quality of life.
A. V. Shabunin +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The history of education in Britain and Ireland: changing perspectives and continuing themes [PDF]
, 2023 Tom Woodin, Susannah Wright
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
TECHNICAL EQUIPMENT AS A DIRECTION OF DEVELOPMENT OF PUBLIC ADMINISTRATION AT THE MODERN STAGE
Публічне управління та регіональний розвитокIn the article summarizes the transformations that affect public administration due to the equipment of spheres, environments, spaces and structures with technical means, which are characterized by wide volumes of functional capacity.
Oleh Bilyk, Olena Zharovska
doaj +1 more source
Related Services Research Project to Support the Education of Students with Deaf-Blindness: Final Report. [PDF]
, 1999 This Final Report documents the activities and products of the . Related Services Research Project to Support the Education of Students with Deafblindness, a four-year research project funded by the U.S.
Giangreco, Michael
core +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source