Results 101 to 110 of about 358,060 (302)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Multivariate measures of positive dependence [PDF]
In this paper a set of desirable properties for measures of positive dependence of ordered n-tuples of continuous random variables (n >= 2) is proposed and a class of multivariate positive dependence measures is introduced. We consider the comonotonicity
Marta Cardin
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Modelling the dependence and internal structure of storm events for continuous rainfall simulation
, 2012 Gyasi-Agyei, Y ORCiD: 0000-0002-2671-1180Pair-copula construction methodology has been explored to model the dependence structure between net storm event depth (R), maximum wet periods’ depth (M), and the total wet periods’ duration (L), noting that the ...
Yeboah Gyasi-Agyei (9800804) +5 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Specification Testing in Nonlinear Time Series with Long-Range Dependence [PDF]
This paper proposes a model specification testing procedure for parametric specification of the conditional mean function in a nonlinear time series model with long–range dependence.
Jiti Gao, Qiying Wang, Jiying Yin
core
Continuous Dependence for an Implicit Nonlinear Equation
Journal of Differential Equations, 1994 Consider the following problem: (1) \(v'(t)+ w(t)+ C(t)u(t)= f(t)\) for a.e. \(t\in (0,T)\), (2) \(v(t)\in A(t)u(t)\), \(w(t)\in B(t)u(t)\) for a.e. \(t\in (0,T)\), (3) \(v(0)= v_ 0\), where \(A(t)\) and \(B(t)\) are maximal monotone and linearly bounded operators in a real Hilbert space \(V\) and \(A(t)+ B(t)\) is \(V\)-coercive.
openaire +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
MAPS OF CONTINUOUS SPATIAL DEPENDENCE [PDF]
Heterogeneity is one of the distinguishing features in spatial econometric models. It is a frequent problem in applied work and can be very damaging for statistical inference.
Jesús MUR, Ana ANGULO, Fernando LOPEZ
core
Continuous dependence of solutions to mixed boundary value problems for a parabolic equation
Electronic Journal of Differential Equations, 2008 We prove the continuous dependence, upon the data, of solutions to second-order parabolic equations. We study two boundary-value problems: One has a nonlocal (integral) condition and the another has a local boundary condition. The proofs are based on
Nikolay Iossifovich Yurchuk +2 more
doaj