Results 71 to 80 of about 2,847,157 (340)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Patient Experience at Discharge: A Quality Improvement Study in an Armed Forces Hospital, Saudi Arabia

open access: yesJournal of Patient Experience
Over the past decade, the health sector of Saudi Arabia has been undergoing a major transformation. This pilot research aimed to improve the patient experience (PX) at discharge by at least 2 scores within 2 years at a King Abdul Aziz Armed Forces ...
Noha Almohaisen BDS, SBARD, MHQS, CPXP, CPHQ, EMBA(c)   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Oklahoma Heart Hospital: Clinician Leaders Establish Culture of Quality [PDF]

open access: yes, 2009
Describes strategies for a culture of quality, including a flat organizational structure, optimal nurse experience and ratios, standardization through care sets, technology-enabled feedback and assessment, and continuous improvement through new ...
Sharon Silow-Carroll
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Disrupting deficit mindsets: mitigating cognition that derails equitable continuous improvement

open access: yesFrontiers in Education
IntroductionContinuous improvement (CI) has transformative potential but far too often that potential is unrealized. Practitioners engaging in CI are frequently guided by mindsets that derail system transformation by shifting the focus from improving ...
Brandi N. Hinnant-Crawford   +2 more
doaj   +1 more source

The „5S” strategy for continuous improvement of the manufacturing processes in autocar exhaust [PDF]

open access: yes
The paper presents a continuous improvement strategy, process-oriented and aiming to improve manufacturing at AUTOCAR EXHAUST. The „5S” rules have immediate and significant effects on the sequence of activities in the work post, thus influencing the ...
Gheorghe DULHAI
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Continuous Improvement in Process Safety Education

open access: yesChemical Engineering Transactions, 2019
The importance of continuous improvement is emphasized in this paper from the perspectives of process safety education in general and university process safety courses in particular.
Paul Amyotte, Faisal Khan, Yene Irvine
doaj   +1 more source

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