Results 41 to 50 of about 88,361 (301)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Engineering Transactions, 2003 The main goal of this paper is to present a computational analysis of damage evolution in adhesive joint connecting composite pipes subjected to cyclic static axial tension with constant amplitude.
Ł. Figiel, M. Kamiński
doaj +1 more source
Development of methologies to study the damage tolerance of aeronautical and aerospace composite structures [PDF]
, 2008 Mechanics of Advanced Materials research group (Department of Continuum Mechanics and Structural Analysis) of the University Carlos III of Madrid (Spain) offers their experience in the analysis and modelization of high and low velocity impact behaviour ...
Barbero Pozuelo, Enrique +1 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Strain capacity assessment of API X65 steel using damage mechanics [PDF]
Fracture and Structural Integrity, 2017 Strain-based design for offshore pipeline requires a considerable experimental work aimed to determine the material fracture toughness and the effective strain capacity of pipe and welds.
Gabriel Testa +6 more
doaj +2 more sources
A fatigue damage meso-model for fiber-reinforced composites with stress ratio effect [PDF]
, 2016 This work presents a fatigue damage meso-model for fiber-reinforced plastic composites, in which the effect of stress ratios on the off-axis fatigue behavior is taken into account.
Scarpa, Fabrizio +3 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Phenomenological modeling of strain hardening, phase transformation and damage effects of trip-steels [PDF]
, 2017 In this study, the constitutive modeling of loading state dependent strain hardening and martensite evolution of high alloyed TRIP-steels are addressed, which are experimentally observed comparing uni-axial tension and compression test results ...
Kuna, Meinhard, Seupel, Andreas
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source