Results 51 to 60 of about 58,852 (305)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Static nonlinear analysis of piles cap based on the Continuum Damage Mechanics

Semina: Ciências Exatas e Tecnológicas, 2015
The piles cap is an important structural element whose function is to transfer the actions of the superstructure for a group of piles. The visual inspection of the piles cap behavior under service conditions is not possible and, in addition, the ...
Luiz Antonio Farani de Souza
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Strain capacity assessment of API X65 steel using damage mechanics [PDF]

Fracture and Structural Integrity, 2017
Strain-based design for offshore pipeline requires a considerable experimental work aimed to determine the material fracture toughness and the effective strain capacity of pipe and welds.
Gabriel Testa, Nicola Bonora, Domenico Gentile, Andrew Ruggiero, Gianluca Iannitti, Antonio Carlucci, Yazid Madi   +6 more
doaj   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

SURVEY OF MODERN TRENDS IN ANALYSIS OF CONTINUUM DAMAGE MECHANICS

TASK Quarterly, 2006
A brief review of the damage mechanics literature is given. As this area of scientific research is very modern, the authors have restricted themselves to about 100 most important books and papers.
ANDRZEJ AMBROZIAK, PAWEŁ KŁOSOWSKI
doaj  

Variational Methods in Continuum Damage and Fracture Mechanics [PDF]

, 2017
Damage is defined as the loss of material stiffness under loading conditions. This process is intrinsically irreversible and, therefore, dissipative. When the stiffness vanishes, fracture is achieved. In order to derive governing equations, variationalmethods have been employed.
Placidi, Luca, Barchiesi, Emilio, Misra, Anil, Andreaus, Ugo   +3 more
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Modeling thermo-mechanical fatigue for rolling die under continuous casting process

Results in Engineering
In the continuous casting process, the rolling die is exposed to non-steady stress conditions that can initiate thermo-mechanical fatigue damage. Understanding the rolling die failure mechanism is essential in metal-forming industries.
Mesay Alemu Tolcha, Hirpa Gelgele Lemu
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source