Results 41 to 50 of about 6,090 (261)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Static nonlinear analysis of piles cap based on the Continuum Damage Mechanics
Semina: Ciências Exatas e Tecnológicas, 2015 The piles cap is an important structural element whose function is to transfer the actions of the superstructure for a group of piles. The visual inspection of the piles cap behavior under service conditions is not possible and, in addition, the ...
Luiz Antonio Farani de Souza
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
SURVEY OF MODERN TRENDS IN ANALYSIS OF CONTINUUM DAMAGE MECHANICS
TASK Quarterly, 2006 A brief review of the damage mechanics literature is given. As this area of scientific research is very modern, the authors have restricted themselves to about 100 most important books and papers.
ANDRZEJ AMBROZIAK, PAWEŁ KŁOSOWSKI
doaj
Variational Methods in Continuum Damage and Fracture Mechanics [PDF]
, 2017 Damage is defined as the loss of material stiffness under loading conditions. This process is intrinsically irreversible and, therefore, dissipative. When the stiffness vanishes, fracture is achieved. In order to derive governing equations, variationalmethods have been employed.
Placidi, Luca +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Modeling thermo-mechanical fatigue for rolling die under continuous casting process
Results in EngineeringIn the continuous casting process, the rolling die is exposed to non-steady stress conditions that can initiate thermo-mechanical fatigue damage. Understanding the rolling die failure mechanism is essential in metal-forming industries.
Mesay Alemu Tolcha, Hirpa Gelgele Lemu
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Analysis of Damage Value of Aluminum Alloys—Application of a Continuum Damage Mechanics Model
Applied MechanicsDamage refers to the degradation of a material subjected to an external condition such as loading, temperature, and environment. Several investigations have been undertaken to understand the damage of materials like steel, aluminum alloy, titanium alloy,
Vishavbandhu Kanwar +2 more
doaj +1 more source