Results 61 to 70 of about 58,852 (305)

Analysis of Damage Value of Aluminum Alloys—Application of a Continuum Damage Mechanics Model

Applied Mechanics
Damage refers to the degradation of a material subjected to an external condition such as loading, temperature, and environment. Several investigations have been undertaken to understand the damage of materials like steel, aluminum alloy, titanium alloy,
Vishavbandhu Kanwar, Vishwanath Managuli, Y. S. Upadhyaya   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The Application of Continuum Damage Mechanics to Fatigue Failure Mechanisms

, 1990
Continuum Damage Mechanics is applied to the modeling of fatigue failure mechanisms. The resulting equations are solved by discretizing the time domain and the space domain. A tremendous reduction of computing times is achieved by uncoupling the constitutive equations and by employing an adaptive stepsize selection procedure.
Paas, M.H.J.W., Schreurs, P.J.G., Janssen, J.D.   +2 more
openaire   +2 more sources

Damage mechanics : basic variables in continuum theories

International Journal of Solids and Structures, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cauvin, Alix, Testa, Rene B.
openaire   +1 more source

Damage related material constants in continuum damage mechanics for unidirectional composites with matrix cracks

International journal of damage mechanics, 2018
Application of a continuum damage mechanics formulation rests on the ease with which the material constants involved in the formulation can be determined. For an initially linear elastic material, the changes in elastic constants induced by damage depend
Shuguang Li, Mingkun Wang, L. Jeanmeure, E. Sitnikova, Fei Yu, Q. Pan, Chuwei Zhou, R. Talreja   +7 more
semanticscholar   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

3D Numerical Solution for Natural Fracture Distribution in Tight-Sand Reservoirs Based on Damage Mechanics with Sets of 2D Seismic Data

Applied Sciences
Natural fracture development in tight-sand gas reservoirs is strongly controlled by tectonic evolution yet remains difficult to characterize using conventional seismic interpretation due to limited resolution. This study presents a damage-mechanics-based
Meng Wang, Xinpu Shen, Qiyu Gao
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source