Results 71 to 80 of about 58,852 (305)

A continuum damage mechanics-based approach for the high cycle fatigue behavior of metallic polycrystals

International journal of damage mechanics, 2018
Polycrystalline elasto-plasticity models provide a general framework for investigating the effect of microstructural heterogeneities (e.g. grains, inclusions, pores) on the high cycle fatigue behavior of metallic materials. In this work, continuum damage
C. Mareau, F. Morel
semanticscholar   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Prediction of Running-in Behavior for Point Contacts under Mixed Lubrication [PDF]

AUT Journal of Mechanical Engineering
Tribology concentrates on wear, lubrication, and friction of interacting surfaces in relative motion. Wear, which is the major reason of material dissipation, evolves in three separate stages: severe wear, steady-state, and running-in.
Sahar Ghatrehsamani, Amir Arsalan Hemmasian, Ali Babasafari Zamani, Saleh Akbarzadeh   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A Non-Linear Model for Corrosion Fatigue Lifetime Based on Continuum Damage Mechanics

MATEC Web of Conferences, 2018
Many structures, such as oil platforms and wind turbines, are built in the marine environment. These structures do not merely suffer from variable cyclic loading due to wind, waves and current, but also from corrosion.
Zhang Jie, Hertelé Stijn, De Waele Wim
doaj   +1 more source

Interaction of damage processes in continuum damage mechanics

Acta Mechanica
Abstract This work presents novel mathematical formulations for the interaction of damage processes within the framework of continuum damage mechanics, focusing on advanced numerical applications. The approach involves an innovative analogy between the decomposition of the damage variable/tensor and the rule of mixtures, leading to both ...
George Z. Voyiadjis, Peter I. Kattan
openaire   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Failure Analysis and Experimental Study on Bolted Composite Joints Based on Continuum Damage Mechanics

Composite structures, 2022
Xi Li, Yazhi Li, Fei Li, Zeng Huang, Hong Chen   +4 more
semanticscholar   +1 more source