Results 71 to 80 of about 2,435,415 (320)
Analysis of Damage Value of Aluminum Alloys—Application of a Continuum Damage Mechanics Model
Applied MechanicsDamage refers to the degradation of a material subjected to an external condition such as loading, temperature, and environment. Several investigations have been undertaken to understand the damage of materials like steel, aluminum alloy, titanium alloy,
Vishavbandhu Kanwar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Variational Methods in Continuum Damage and Fracture Mechanics [PDF]
, 2017 Damage is defined as the loss of material stiffness under loading conditions. This process is intrinsically irreversible and, therefore, dissipative. When the stiffness vanishes, fracture is achieved. In order to derive governing equations, variationalmethods have been employed.
Placidi, Luca +3 more
openaire +1 more source
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
The Application of Continuum Damage Mechanics to Fatigue Failure Mechanisms
, 1990 Continuum Damage Mechanics is applied to the modeling of fatigue failure mechanisms. The resulting equations are solved by discretizing the time domain and the space domain. A tremendous reduction of computing times is achieved by uncoupling the constitutive equations and by employing an adaptive stepsize selection procedure.
Paas, M.H.J.W. +2 more
openaire +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Continuum Damage-Healing Mechanics with Introduction to New Healing Variables
, 2012 In this study, damage and healing mechanisms are discussed in detail with special emphasis given on two new healing variables. They are introduced in terms of healing variable based on area and healing variable based on elastic stiffness.
George Voyiadjis
core +1 more source
International journal of damage mechanics, 2018 Application of a continuum damage mechanics formulation rests on the ease with which the material constants involved in the formulation can be determined. For an initially linear elastic material, the changes in elastic constants induced by damage depend
Shu-Guang Li +7 more
semanticscholar +1 more source
Damage mechanics : basic variables in continuum theories
International Journal of Solids and Structures, 1999 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Cauvin, Alix, Testa, Rene B.
openaire +1 more source