Results 71 to 80 of about 89,082 (299)
Applied SciencesNatural fracture development in tight-sand gas reservoirs is strongly controlled by tectonic evolution yet remains difficult to characterize using conventional seismic interpretation due to limited resolution. This study presents a damage-mechanics-based
Meng Wang, Xinpu Shen, Qiyu Gao
doaj +1 more source
3D numerical modelling of twisting cracks under bending and torsion of skew notched beams [PDF]
, 2017 The testing of mode III and mixed mode failure is every so often encountered in the dedicated literature of mechanical characterization of brittle and quasi-brittle materials.
Benedetti, Lorenzo +2 more
core +5 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Prediction of Running-in Behavior for Point Contacts under Mixed Lubrication [PDF]
AUT Journal of Mechanical EngineeringTribology concentrates on wear, lubrication, and friction of interacting surfaces in relative motion. Wear, which is the major reason of material dissipation, evolves in three separate stages: severe wear, steady-state, and running-in.
Sahar Ghatrehsamani +3 more
doaj +1 more source
Progressive failure methodologies for predicting residual strength and life of laminated composites [PDF]
Two progressive failure methodologies currently under development by the Mechanics of Materials Branch at NASA Langley Research Center are discussed. The damage tolerance/fail safety methodology developed by O'Brien is an engineering approach to ensuring
Allen, David H. +2 more
core +1 more source
Неизотермическая ползучесть и повреждаемость элементов паровых турбин [PDF]
, 2006 The conventional Kachanov-Rabotnov-Hayhurst type continuum damage mechanics creep model is extended to the case of variable temperature and strain hardening consideration. Both the creep and the damage rates are assumed temperature dependent. A technique
Гораш, Е. Н. +2 more
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A 1D continuum model for beams with pantographic microstructure: asymptotic micro-macro identification and numerical results [PDF]
, 2018 In the standard asymptotic micro-macro identification theory, starting from a De Saint-Venant cylinder, it is possible to prove that, in the asymptotic limit, only flexible, inextensible, beams can be obtained at the macro-level.
Barchiesi, Emilio +4 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Computational model for local damage assesment of structures [PDF]
, 1998 In the last years many studies have been developed to analyze the seismic behavior throug the damage concept. In fact, the evaluation of the structural damage is important in order to quantify the safety of new and existing structures and, also, to ...
Alarcón Álvarez, Enrique +3 more
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