Results 61 to 70 of about 88,361 (301)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Analysis of Damage Value of Aluminum Alloys—Application of a Continuum Damage Mechanics Model

Applied Mechanics
Damage refers to the degradation of a material subjected to an external condition such as loading, temperature, and environment. Several investigations have been undertaken to understand the damage of materials like steel, aluminum alloy, titanium alloy,
Vishavbandhu Kanwar, Vishwanath Managuli, Y. S. Upadhyaya   +2 more
doaj   +1 more source

Characterization of Discontinuity and Mechanical Anisotropy of Shale Based on Continuum Damage Mechanics

Geofluids, 2021
The effect of the bedding structure on the mechanical properties of layered shale was studied by means of experiment and numerical simulation. Based on continuum damage theory and discrete fracture network modeling method (D-DFN), a finite element model ...
Qinglin Shan, Peng Yan, Hengjie Luan, Yujing Jiang, Sunhao Zhang   +4 more
doaj   +1 more source

Computational model for local damage assesment of structures [PDF]

, 1998
In the last years many studies have been developed to analyze the seismic behavior throug the damage concept. In fact, the evaluation of the structural damage is important in order to quantify the safety of new and existing structures and, also, to ...
Alarcón Álvarez, Enrique, Carnicero, Alberto, Flórez-López, Julio, Perera Velamazán, Ricardo   +3 more
core  

A multi-level interface model for damaged masonry [PDF]

, 2013
The aim of the present work is to propose a new micro-mechanical model in the context of the deductive approach used to derive interface models. This model, based on a previous study introduced previously by A. Rekik and F.
Lebon, Frédéric, Raffa, Maria Letizia, Sacco, Elio, Welemane, Hélène   +3 more
core   +3 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Analysis of damage and fracture formulations in cold extrusion [PDF]

, 2017
In forming processes, components generally undergo large deformations. This induces the evolution of damage, which can influence material and product properties.
Clausmeyer, Till, Schowtjak, Alexander, Tekkaya, A. Erman   +2 more
core  

Cracking in asphalt materials [PDF]

, 2018
This chapter provides a comprehensive review of both laboratory characterization and modelling of bulk material fracture in asphalt mixtures. For the purpose of organization, this chapter is divided into a section on laboratory tests and a section on ...
AF Braham, Armelle Chabot, B Behnia, B Birgisson, B Delaporte, B Kim, BS Underwood, C Huet, D Bodin, D Bodin, Didier Bodin, DV Ramsamooj, Emmanuel Chailleux, Eshan V. Dave, Eshan V. Dave, Eshan V. Dave, F Dubois, F Dubois, F Dubois, F Jiang, GR Chehab, H Benedetto Di, H Benedetto Di, H Lemaistre, HJ Lee, HM Nguyen, J Mandel, JF Corte, JS Daniel, K Majidzadeh, Malcolm L. Williams, MJ Jacobs, MJ Lamborn, MP Wagoner, MP Wagoner, N Tapsoba, NH Gibson, R Roque, R Roque, R. A. Schapery, RA Schapery, RA Schapery, RA Schapery, S Ahmed, S Ahmed, S Ahmed, SH Song, Simon Pouget, SW Park, T Hou, Xinjun Li, YR Kim, YR Kim, YR Kim, YR Kim, Z Zhang, Z Zhang   +56 more
core   +5 more sources

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations [PDF]

, 2012
This conference paper presents the current research of preliminary analysing of experimental data for the development of high Cr Alloy Creep damage Constitutive Equations (such as P91 alloy). Firstly, it briefly introduces the background of general creep
An, Lili, Lu, Zhongyu, Xu, Donglai, Xu, Qiang   +3 more
core