Chronic Diseases and Translational Medicine, EarlyView.Pharmacological mechanisms and physiologic effects of GLP‐1 receptor agonists relevant to peri‐endoscopic risk. ABSTRACT The global increase in obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD) has led to a higher use of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) among patients ...
Junaid Beig +7 more
wiley +1 more source
TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis. [PDF]
J Cell Biol, 2018 Mangal S +7 more
europepmc +1 more source
Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review
ChemFoodChem, EarlyView.ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida +7 more
wiley +1 more source
Cdk1-dependent phosphoinhibition of a formin-F-BAR interaction opposes cytokinetic contractile ring formation. [PDF]
Mol Biol Cell, 2018 Willet AH, Bohnert KA, Gould KL.
europepmc +1 more source
Cytoskeleton, EarlyView.ABSTRACT Arp2/3 complex is a seven‐component protein complex that facilitates the assembly of branched actin filament networks by binding to pre‐existing “mother” actin filaments and initiating the nucleation of new branched “daughter” filaments. Arp2/3 complex must be activated by a nucleation promoting factor such as the WASP/Scar protein family. The
Caitlin A. Anderson +8 more
wiley +1 more source
Labeling Strategies for Monitoring Cytoskeleton Dynamics in Cultured Epithelial Cells
Cytoskeleton, EarlyView.ABSTRACT Collective cell migration relies on coordinated cytoskeletal remodeling, yet the impact of live‐cell actin filament probes on these dynamics remains poorly characterized. Here, we systematically compared the performance and cellular effects of fluorogenic jasplakinolide‐based probes, SiR‐actin and SiR‐XActin, with the genetically encoded ...
Victoria Levario‐Diaz +6 more
wiley +1 more source
ER-PM Contacts Define Actomyosin Kinetics for Proper Contractile Ring Assembly. [PDF]
Curr Biol, 2016 Zhang D, Bidone TC, Vavylonis D.
europepmc +1 more source
Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle
Developmental Dynamics, EarlyView.Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell +3 more
wiley +1 more source
LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring. [PDF]
Mol Biol Cell, 2017 Price KL, Rose LS.
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Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy
ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo +7 more
wiley +1 more source