Results 1 to 10 of about 248,671 (308)

Increased contractility affects left ventricular kinetic energy in pulmonary hypertension [PDF]

Physiological Reports
Precapillary pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance (PVR), with progressively altered right (RV) and left ventricular (LV) hemodynamics and function.
E. Bergström, K. Pola, B. Kjellström, J. Töger, P. M. Arvidsson, M. Carlsson, G. Rådegran, H. Arheden, E. Ostenfeld   +8 more
doaj   +2 more sources

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

eLife, 2022
Cancer cell migration is highly heterogeneous, and the migratory capability of cancer cells is thought to be an indicator of metastatic potential. It is becoming clear that a cancer cell does not have to be inherently migratory to metastasize, with ...
Samantha C Schwager, Katherine M Young, Lauren A Hapach, Caroline M Carlson, Jenna A Mosier, Tanner J McArdle, Wenjun Wang, Curtis Schunk, Anissa L Jayathilake, Madison E Bates, Francois Bordeleau, Marc A Antonyak, Richard A Cerione, Cynthia A Reinhart-King   +13 more
doaj   +1 more source

Hypercontractile cardiac phenotype in mice overexpressing the regulatory subunit PR72 of protein phosphatase 2A

Frontiers in Cardiovascular Medicine, 2023
BackgroundThe activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits.
Julius R. Herting, Jule H. König, Katarina Hadova, Alexander Heinick, Frank U. Müller, Paul Pauls, Matthias D. Seidl, Carolina Soppa, Uwe Kirchhefer   +8 more
doaj   +1 more source

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system [PDF]

, 2012
ATP-dependent paracrine signaling, mediated via the release of ATP through plasma membrane-embedded hemichannels of the connexin family, coordinates a synchronized response between neighboring cells.
Bultynck, Geert, D'Hondt, Catheleyne, Hertens, Fréderic, Himpens, Bernard, Leybaert, Luc, Parys, Jan B, Ponsaerts, Raf, Vereecke, Johan   +7 more
core   +14 more sources

Diverse integrin adhesion stoichiometries caused by varied actomyosin activity [PDF]

Open Biology, 2017
Cells in an organism are subjected to numerous sources of external and internal forces, and are able to sense and respond to these forces. Integrin-mediated adhesion links the extracellular matrix outside cells to the cytoskeleton inside, and ...
Natalia A. Bulgakova, Jutta Wellmann, Nicholas H. Brown   +2 more
doaj   +1 more source

Dexamethasone Treatment Preserves the Structure of Adult Cardiac Explants and Supports Their Long-Term Contractility In Vitro

International Journal of Translational Medicine, 2023
Normal contractile function of the myocardium is essential for optimal cardiovascular health. Evaluating drug effects on cardiomyocyte function at the cellular level is difficult for long-term studies.
Leonard M. Eisenberg, Keerat Kaur, John M. Castillo, John G. Edwards, Carol A. Eisenberg   +4 more
doaj   +1 more source

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na⁺,K⁺-ATPase α₂-Isoform

Cells, 2023
Two α-isoforms of the Na+,K+-ATPase (α1 and α2) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility.
Rajkumar Rajanathan, Clàudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov   +8 more
doaj   +1 more source

Functional differences in human aortic valve interstitial cells from patients with varying calcific aortic valve disease

Frontiers in Physiology, 2023
Calcific aortic valve disease (CAVD) is characterized by progressive stiffening of aortic valve (AV) tissues, inducing stenosis and insufficiency. Bicuspid aortic valve (BAV) is a common congenital defect in which the AV has two leaflets rather than ...
Robin Tuscher, Alex Khang, Toni M. West, Chiara Camillo, Giovanni Ferrari, Michael S. Sacks   +5 more
doaj   +1 more source

HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension

Pharmaceutics, 2022
We recently established a large animal model that recapitulates key clinical features of heart failure with preserved ejection fraction (HFpEF) and tested the effects of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).
Deborah M. Eaton, Thomas G. Martin, Michael Kasa, Natasa Djalinac, Senka Ljubojevic-Holzer, Dirk Von Lewinski, Maria Pöttler, Theerachat Kampaengsri, Andreas Krumphuber, Katharina Scharer, Heinrich Maechler, Andreas Zirlik, Timothy A. McKinsey, Jonathan A. Kirk, Steven R. Houser, Peter P. Rainer, Markus Wallner   +16 more
doaj   +1 more source

Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function

Frontiers in Physiology, 2020
Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of ...
John Malysz, Georgi V. Petkov, Georgi V. Petkov, Georgi V. Petkov   +3 more
doaj   +1 more source