Results 31 to 40 of about 160,172 (303)

Guanidine Affects Differentially the Twitch Response of Diaphragm, Extensor Digitorum Longus and Soleus Nerve-Muscle Preparations of Mice

Molecules, 2012
Guanidine has been used with some success to treat myasthenia gravis and myasthenic syndrome because it increases acetylcholine release at nerve terminals through K⁺, Na⁺ and Ca²⁺ ...
Maria Alice da Cruz Höfling, Rosana Ferrari, Léa Rodrigues-Simioni   +2 more
doaj   +1 more source

Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction. [PDF]

, 2017
Chronic urethral obstruction and the ensuing bladder wall remodeling can lead to diminished bladder smooth muscle (BSM) contractility and debilitating lower urinary tract symptoms.
Ali Hashemi Gheinani, Cristofaro, Vivian, Hashemi Gheinani, Ali, Fiona C. Burkhard, Sullivan, Maryrose P, Adam, Rosalyn M, Vasquez, Evalynn, Evalynn Vasquez, Vivian Cristofaro, Stefan Lukianov, Katia Monastyrskaya, Diane R. Bielenberg, Lukianov, Stefan, Maryrose P. Sullivan, Monastyrskaya-Stäuber, Katia, Rosalyn M. Adam, Burkhard, Fiona C., Bielenberg, Diane R   +17 more
core   +1 more source

RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific [PDF]

, 2004
Hypoxia induces vasoconstriction of pulmonary arteries through contraction of smooth muscle cells (SMCs). The GTPase RhoA regulates smooth muscle contractility and actin cytoskeletal remodeling through the Rho-associated kinase ( ROCK).
Bailly, K, Ridley, A J, Haworth, SG, Ridley, AJ, Hall, SM, Hall, S M, Haworth, S G   +6 more
core   +1 more source

Pharmacological modulation of prostaglandin E2 (PGE2) EP receptors improves cardiomyocyte function under hyperglycemic conditions

Physiological Reports, 2022
Type 2 diabetes (T2D) affects >30 million Americans and nearly 70% of individuals with T2D will die from cardiovascular disease (CVD). Circulating levels of the inflammatory signaling lipid, prostaglandin E2 (PGE2), are elevated in the setting of obesity
Karin J. Bosma, Monica Ghosh, Spencer R. Andrei, Lin Zhong, Jennifer C. Dunn, Valerie F. Ricciardi, Juliann B. Burkett, Antonis K. Hatzopoulos, Derek S. Damron, Maureen Gannon   +9 more
doaj   +1 more source

Perioperative Fluid Accumulation Impairs Intestinal Contractility to a Smilar Extent as Peritonitis and Endotoxemia [PDF]

, 2018
BACKGROUND: Perioperative resuscitation with large amounts of fluid may cause tissue edema, especially in the gut, and thereby impair its functions. This is especially relevant in sepsis where capillaries become leaky and fluid rapidly escapes to the ...
Hendrik Bracht, Jakob, Stephan, José Gorrasi, Jukka Takala, Sebastian Brandt, Brügger, Lukas, Gorrasi, José Antonio, Tovar, Luis Antonio, Takala, Jukka, Balsiger, Bruno Markus, Stephan M. Jakob, Bracht, Hendrik, Luis Tovar, Bruno Balsiger, Brandt, Sebastian, Lukas E. Bruegger   +15 more
core   +1 more source

Platelet Contractile Proteins [PDF]

Thrombosis and Haemostasis, 1977
Platelets contain a high concentration of the contractile proteins actin and myosin. The properties of these proteins are generally similar to their counterparts in muscle, suggesting that the platelet actin and myosin can generate contractile force.
openaire   +3 more sources

Contraction of Stress Fibers Extracted from Smooth Muscle Cells: Effects of Varying Ionic Strength

Journal of Biomechanical Science and Engineering, 2012
Actin stress fibers (SFs) play a key role in regulation of cell adhesion, but the biochemical and biophysical properties intrinsic to SFs remain unclear. Here we extracted SFs from rat embryonic smooth muscle cells by deroofing, and evaluated the effects
Shinji DEGUCHI, Tsubasa S. MATSUI, Daiki KOMATSU, Masaaki SATO   +3 more
doaj   +1 more source

Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series

Frontiers in Pharmacology, 2023
Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the myometrium.
Leonie Zurfluh, Marialuigia Giovannini Spinelli, Marialuigia Giovannini Spinelli, Cornelia Betschart, Ana Paula Simões-Wüst, Ana Paula Simões-Wüst   +5 more
doaj   +1 more source

Muscle contractility in spinobulbar muscular atrophy [PDF]

, 2019
Spinobulbar muscular atrophy (SBMA) is caused by a trinucleotide repeat expansion in the androgen receptor gene on the X chromosome. There is a toxic effect of the mutant receptor on muscle and neurons resulting in muscle weakness and atrophy.
Vissing, John, Oestergaard, Sofie T., Thomsen, Carsten, Dahlqvist, Julia R., Knak, Kirsten Lykke, Poulsen, Nanna S   +5 more
core   +1 more source

Cellular contractility requires ubiquitin mediated proteolysis. [PDF]

, 2009
BACKGROUND:Cellular contractility, essential for cell movement and proliferation, is regulated by microtubules, RhoA and actomyosin. The RhoA dependent kinase ROCK ensures the phosphorylation of the regulatory Myosin II Light Chain (MLC) Ser19, thereby ...
Oren Feine, Hochegger Helfrid, Helfrid Hochegger, Bershadsky Alexander, Brandeis M., Michael Brandeis, Bershadsky A., Cinnamon Y., Alexander Bershadsky, Feine O., Yuval Cinnamon, Hochegger H., Cinnamon Yuval, Feine Oren, Brandeis Michael   +14 more
core   +1 more source