Results 51 to 60 of about 160,172 (303)

Diverse integrin adhesion stoichiometries caused by varied actomyosin activity [PDF]

Open Biology, 2017
Cells in an organism are subjected to numerous sources of external and internal forces, and are able to sense and respond to these forces. Integrin-mediated adhesion links the extracellular matrix outside cells to the cytoskeleton inside, and ...
Natalia A. Bulgakova, Jutta Wellmann, Nicholas H. Brown   +2 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

eLife, 2022
Cancer cell migration is highly heterogeneous, and the migratory capability of cancer cells is thought to be an indicator of metastatic potential. It is becoming clear that a cancer cell does not have to be inherently migratory to metastasize, with ...
Samantha C Schwager, Katherine M Young, Lauren A Hapach, Caroline M Carlson, Jenna A Mosier, Tanner J McArdle, Wenjun Wang, Curtis Schunk, Anissa L Jayathilake, Madison E Bates, Francois Bordeleau, Marc A Antonyak, Richard A Cerione, Cynthia A Reinhart-King   +13 more
doaj   +1 more source

Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium [PDF]

, 2013
The existence of opioid receptors in mammalian myometrial tissue is now widely accepted. Previously enkephalin degrading enzymes have been shown to be elevated in pregnant rat uterus and a met-enkephalin analogue has been shown to alter spontaneous ...
McMorrow, Jason P., Carey, Michael F., Campion, Deirdre P., O\u27Connor, J. J., Fanning, Rebecca A., O'Connor, J. J.   +5 more
core   +1 more source

Microenvironmental Reprogramming by 3D Anisotropic Cardiac Extracellular Matrix Induces Nuclear Remodeling and Epigenetic Maturation of Chemically Induced Cardiomyocytes

Advanced Functional Materials, EarlyView.
A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo, Mi Jeong Lee, Hyun Wook Kang, Seonhee Byeon, Soo‐Kyoung Choi, Nakwon Choi, Seung‐Woo Cho, Yoonhee Jin   +7 more
wiley   +1 more source

Differential effects of anaesthesia on the contractility of lymphatic vessels in vivo. [PDF]

, 2019
KEY POINTS Contractility of lymphatic collectors is essential for the functionality of the lymphatic system and, thus, for lymph flow. Previously published rates of lymphatic collectors in mice vary from 1.1 to 17 contractions/min with little ...
Miriam Ries, Steven T. Proulx, Yuliang He, Detmar, Michael, Proulx, Steven T., Ries, Miriam, Samia B. Bachmann, Bachmann, Samia B., Ries, Miriam; id_orcid, He, Yuliang, Bachmann, Samia B, Michael Detmar, Proulx, Steven Thomas   +12 more
core   +2 more sources

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Regulation of Actin Dynamics in the C. elegans Somatic Gonad

Journal of Developmental Biology, 2019
The reproductive system of the hermaphroditic nematode C. elegans consists of a series of contractile cell types—including the gonadal sheath cells, the spermathecal cells and the spermatheca–uterine valve—that contract in a coordinated
Charlotte A. Kelley, Erin J Cram
doaj   +1 more source

Deep tissue contractility sensing with biointegrated microlasers

, 2021
Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a ...
Woolfson, Lewis, Morton, Andrew, Tucker, Carl S., Caixeiro, Soraya, Gather, Malte C., Appleton, Paul L.; id_orcid, Barnard, Isla R.M.; id_orcid, Miles, Gareth B., Pitt, Samantha J., Robertson, Gavin B., Casement, Becky, Schubert, Marcel, Dorward, Amy M.   +12 more
core   +4 more sources

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source