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Current Biology, 2003 What is it? The contractile ring is a ring-shaped structure located just beneath the plasma membrane at the future division site in many, though not all, eukaryotic cell types. Composed of actin, myosin and many other proteins, it assembles in anaphase and contracts as cells divide. The contractile ring is responsible for cytokinesis in many eukaryotic
Chang, Fred, Burgess, David
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Contractility in an extensile system [PDF]
Soft Matter, 2017 Essentially all biology is active and dynamic. Biological entities autonomously sense, com- pute, and respond using energy-coupled ratchets that can produce force and do work. The cytoskeleton, along with its associated proteins and motors, is a canonical example of biological active matter, which is responsible for cargo transport, cell motility ...
Kasimira T. Stanhope +3 more
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Analysis of Contractility and Invasion Potential of Two Canine Mammary Tumor Cell Lines
Frontiers in Veterinary Science, 2017 Cancer cells are surrounded by a mechanically and biochemically distinct microenvironment that undergoes dynamic changes throughout the neoplastic progression.
Kaisa Rajakylä +2 more
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AI-Based Estimation of End-Systolic Elastance From Arm-Pressure and Systolic Time Intervals
Frontiers in Artificial Intelligence, 2021 Left ventricular end-systolic elastance (Ees) is a major determinant of cardiac systolic function and ventricular-arterial interaction. Previous methods for the Ees estimation require the use of the echocardiographic ejection fraction (EF).
Vasiliki Bikia +4 more
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Contractility and Conformation [PDF]
The Journal of General Physiology, 1967 Contractility in fibers can arise from changes of macromolecular conformation caused by changes in some thermodynamic variable such as temperature, pH, or solvent composition. Illustrations are given of contractile processes in fibers and of changes in macromolecular conformation in dilute solution. These may involve order-disorder transitions, e.g. of
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Frontiers in Physiology, 2018 Pirfenidone (PFD) is used to treat human pulmonary fibrosis. Its administration to animals with distinct forms of cardiovascular disease results in striking improvement in cardiac performance.
Adrián Monsalvo-Villegas +2 more
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Pathophysiological Mechanisms of Cardiac Dysfunction in Transgenic Mice with Viral Myocarditis
Cells, 2023 Viral myocarditis is pathologically associated with RNA viruses such as coxsackievirus B3 (CVB3), or more recently, with SARS-CoV-2, but despite intensive research, clinically proven treatment is limited.
Matthias Rohrbeck +22 more
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Frontiers in Bioengineering and Biotechnology, 2021 Determination of left ventricular (LV) end-systolic elastance (Ees) is of utmost importance for assessing the cardiac systolic function and hemodynamical state in humans. Yet, the clinical use of Ees is not established due to the invasive nature and high
Vasiliki Bikia +6 more
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Force Measurements From Myofibril to Filament
Frontiers in Physiology, 2022 Contractility, the generation of force and movement by molecular motors, is the hallmark of all muscles, including striated muscle. Contractility can be studied at every level of organization from a whole animal to single molecules.
Steven Marston
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Current Biology, 2011 What is the contractile ring? During cell division, the contractile ring generates the constricting force to separate one cell into two cells. Formed during cytokinesis, the last step of cell division, the contractile ring is composed of filamentous actin (F-actin) and the motor protein myosin-2, along with additional structural and regulatory proteins.
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