Results 1 to 10 of about 164,093 (312)

Morphological changes in the arterial pressure waveform following hemodynamic therapies in critical care: A clinical proof‐of‐concept study in older adults [PDF]

Physiological Reports
Clinical management of hemodynamic instability remains challenging as underlying mechanisms are complex. A recent in‐silico study showed that peripheral arterial waveform analysis can differentiate deficits in preload, afterload, and contractility.
F. M. deRaat, M. P. Mulder, A. J. R. De Bie Dekker, A. R. Bouwman, L. J. Montenij, D. W. Donker   +5 more
doaj   +2 more sources

Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series

Frontiers in Pharmacology, 2023
Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the myometrium.
Leonie Zurfluh, Marialuigia Giovannini Spinelli, Marialuigia Giovannini Spinelli, Cornelia Betschart, Ana Paula Simões-Wüst, Ana Paula Simões-Wüst   +5 more
doaj   +1 more source

Diverse integrin adhesion stoichiometries caused by varied actomyosin activity [PDF]

Open Biology, 2017
Cells in an organism are subjected to numerous sources of external and internal forces, and are able to sense and respond to these forces. Integrin-mediated adhesion links the extracellular matrix outside cells to the cytoskeleton inside, and ...
Natalia A. Bulgakova, Jutta Wellmann, Nicholas H. Brown   +2 more
doaj   +1 more source

Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

eLife, 2022
Cancer cell migration is highly heterogeneous, and the migratory capability of cancer cells is thought to be an indicator of metastatic potential. It is becoming clear that a cancer cell does not have to be inherently migratory to metastasize, with ...
Samantha C Schwager, Katherine M Young, Lauren A Hapach, Caroline M Carlson, Jenna A Mosier, Tanner J McArdle, Wenjun Wang, Curtis Schunk, Anissa L Jayathilake, Madison E Bates, Francois Bordeleau, Marc A Antonyak, Richard A Cerione, Cynthia A Reinhart-King   +13 more
doaj   +1 more source

The contractile ring [PDF]

Current Biology, 2003
What is it? The contractile ring is a ring-shaped structure located just beneath the plasma membrane at the future division site in many, though not all, eukaryotic cell types. Composed of actin, myosin and many other proteins, it assembles in anaphase and contracts as cells divide. The contractile ring is responsible for cytokinesis in many eukaryotic
Chang, Fred, Burgess, David
openaire   +2 more sources

Dexamethasone Treatment Preserves the Structure of Adult Cardiac Explants and Supports Their Long-Term Contractility In Vitro

International Journal of Translational Medicine, 2023
Normal contractile function of the myocardium is essential for optimal cardiovascular health. Evaluating drug effects on cardiomyocyte function at the cellular level is difficult for long-term studies.
Leonard M. Eisenberg, Keerat Kaur, John M. Castillo, John G. Edwards, Carol A. Eisenberg   +4 more
doaj   +1 more source

HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension

Pharmaceutics, 2022
We recently established a large animal model that recapitulates key clinical features of heart failure with preserved ejection fraction (HFpEF) and tested the effects of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).
Deborah M. Eaton, Thomas G. Martin, Michael Kasa, Natasa Djalinac, Senka Ljubojevic-Holzer, Dirk Von Lewinski, Maria Pöttler, Theerachat Kampaengsri, Andreas Krumphuber, Katharina Scharer, Heinrich Maechler, Andreas Zirlik, Timothy A. McKinsey, Jonathan A. Kirk, Steven R. Houser, Peter P. Rainer, Markus Wallner   +16 more
doaj   +1 more source

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na⁺,K⁺-ATPase α₂-Isoform

Cells, 2023
Two α-isoforms of the Na+,K+-ATPase (α1 and α2) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility.
Rajkumar Rajanathan, Clàudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov   +8 more
doaj   +1 more source

Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function

Frontiers in Physiology, 2020
Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of ...
John Malysz, Georgi V. Petkov, Georgi V. Petkov, Georgi V. Petkov   +3 more
doaj   +1 more source

Contractility in an extensile system [PDF]

Soft Matter, 2017
Essentially all biology is active and dynamic. Biological entities autonomously sense, com- pute, and respond using energy-coupled ratchets that can produce force and do work. The cytoskeleton, along with its associated proteins and motors, is a canonical example of biological active matter, which is responsible for cargo transport, cell motility ...
Kasimira T. Stanhope, Vikrant Yadav, Christian D. Santangelo, Jennifer L. Ross   +3 more
openaire   +3 more sources