Results 1 to 10 of about 217,710 (307)

Suppression of lusitropy as a disease mechanism in cardiomyopathies

Frontiers in Cardiovascular Medicine, 2023
In cardiac muscle the action of adrenaline on β1 receptors of heart muscle cells is essential to adjust cardiac output to the body’s needs. Adrenergic activation leads to enhanced contractility (inotropy), faster heart rate (chronotropy) and faster ...
Steven Marston, Jose Renato Pinto
doaj   +1 more source

Child’s heart development and contractility from prenatal to postnatal period

Российский кардиологический журнал, 2022
This literature review analyzes current data on the main stages of child’s heart contractility development from prenatal to postnatal period. The presented information will expand the conventional ideas on the age-related cardiovascular physiology in ...
E. N. Pavlyukova, M. V. Kolosova, A. I. Unasheva, G. V. Neklyudova, R. S. Karpov   +4 more
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Long Prehensile Protrusions Can Facilitate Cancer Cell Invasion through the Basement Membrane

Cells, 2023
A basic process in cancer is the breaching of basement-membrane barriers to permit tissue invasion. Cancer cells can use proteases and physical mechanisms to produce initial holes in basement membranes, but how cells squeeze through this barrier into ...
Shayan S. Nazari, Andrew D. Doyle, Christopher K. E. Bleck, Kenneth M. Yamada   +3 more
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A novel method to extend viability and functionality of living heart slices

Frontiers in Cardiovascular Medicine, 2023
Living heart slices have recently emerged as a powerful experimental model for fundamental cardiac research. By retaining the structure and function of the native myocardium while maintaining the simplicity of cell culture models, heart slices can be ...
Abigail J. Ross, Iva Krumova, Berfin Tunc, Qin Wu, Qin Wu, Changhao Wu, Patrizia Camelliti   +6 more
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Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis

Frontiers in Cell and Developmental Biology, 2022
Multiple parallels exist between placentation and cancer dissemination at molecular, cellular, and anatomical levels, presenting placentation as a unique model to mechanistically understand the onset of cancer metastasis.
Junaid Afzal, Wenqiang Du, Ashkan Novin, Yamin Liu, Khadija Wali, Anarghya Murthy, Ashley Garen, Gunter Wagner, Gunter Wagner, Kshitiz, Kshitiz   +10 more
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Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation

Frontiers in Physiology, 2020
Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the ...
Marcel Groen, Alfredo Jesus López-Dávila, Stefan Zittrich, Gabriele Pfitzer, Robert Stehle   +4 more
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C‐type natriuretic peptide induces inotropic and lusitropic effects in human 3D‐engineered cardiac tissue: Implications for the regulation of cardiac function in humans

Experimental Physiology, 2023
The role of C‐type natriuretic peptide (CNP) in the regulation of cardiac function in humans remains to be established as previous investigations have been confined to animal model systems.
Julian C. Bachmann, Jeppe E. Kirchhoff, Julia E. Napolitano, Steve Sorota, William M. Gordon, Nicole Feric, Roozbeh Aschar‐Sobbi, Juan Lv, Zhiyou Cao, Ken Coppieters, Giulia Borghetti, Michael Nyberg   +11 more
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Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayers

eLife, 2021
A monolayer of highly motile cells can establish long-range orientational order, which can be explained by hydrodynamic theory of active gels and fluids.
Tianfa Xie, Sarah R St Pierre, Nonthakorn Olaranont, Lauren E Brown, Min Wu, Yubing Sun   +5 more
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Noninvasive identification and therapeutic implications of supernormal left ventricular contractile phenotype [PDF]

Exploration of Cardiology
Left ventricular (LV) function is typically evaluated through LV ejection fraction (EF), a robust indicator of risk, showing a nonlinear increase in mortality rates below 40%.
Yi Wang, Lixue Yin
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Regulation of Papillary Muscle Contractility by NAD and Ammonia Interplay: Contribution of Ion Channels and Exchangers

Membranes, 2022
Various models, including stem cells derived and isolated cardiomyocytes with overexpressed channels, are utilized to analyze the functional interplay of diverse ion currents involved in cardiac automaticity and excitation–contraction coupling control ...
Alexey S. Averin, Maxim V. Konakov, Oleg Y. Pimenov, Miliausha H. Galimova, Alexey V. Berezhnov, Miroslav N. Nenov, Vladimir V. Dynnik   +6 more
doaj   +1 more source