Results 11 to 20 of about 254,999 (359)

Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series

Frontiers in Pharmacology, 2023
Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the myometrium.
Leonie Zurfluh, Marialuigia Giovannini Spinelli, Marialuigia Giovannini Spinelli, Cornelia Betschart, Ana Paula Simões-Wüst, Ana Paula Simões-Wüst   +5 more
doaj   +1 more source

Changes and classification in myocardial contractile function in the left ventricle following acute myocardial infarction [PDF]

, 2017
In this research, we hypothesized that novel biomechanical parameters are discriminative in patients following acute ST-segment elevation myocardial infarction (STEMI).
Aderhold, Andrej, Berry, Colin, Gao, Hao, Husmeier, Dirk, Luo, Xiaoyu, Mangion, Kenneth   +5 more
core   +1 more source

The cardiac work-loop technique:An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles [PDF]

, 2020
The cardiac work-loop technique closely mimics the intrinsic in vivo movement and characteristics of cardiac muscle function. In this study, six known inotropes were profiled using the work-loop technique to evaluate the potential of this method to ...
AJ Taberner, AM Aylin, AW Tank, CW Scott, D Burkhoff, D Mehra, DA Eisner, DM Bers, DR Varma, E Takimoto, FG Spinale, H Lüllman, J Layland, J Layland, J Layland, J Layland, J Layland, J Tallis, JI Schwartz, JJ Lynch, JL Holtzman, JR Blinks, JS Landzberg, K Noguchi, K Sagawa, KC Vinnakota, L Batista, L Brown, L Butler, L Guo, LJ Mellors, M Eichelbaum, M Gharanei, MA Rosic, ME Conolly, MF Peters, MS Parmacek, P Bergson, R Beigel, R Josephson, R Lewis, R Seifert, R Zhang, RA Nishimura, RC Heel, RD Olson, RK Josephson, RM Bell, RS James, T Akera, T Bombardini, T Delhaas, VJ Caiozzo, W Kerns, W Semafuko, WA Catterall, Y Kihara   +56 more
core   +1 more source

Assembly and positioning of actomyosin rings by contractility and planar cell polarity

eLife, 2015
The actomyosin cytoskeleton is a primary force-generating mechanism in morphogenesis, thus a robust spatial control of cytoskeletal positioning is essential.
Ivonne M Sehring, Pierre Recho, Elsa Denker, Matthew Kourakis, Birthe Mathiesen, Edouard Hannezo, Bo Dong, Di Jiang   +7 more
doaj   +1 more source

Myocardial Contractility: Historical and Contemporary Considerations

Frontiers in Physiology, 2020
The term myocardial contractility is thought to have originated more than 125 years ago and has remained and enigma ever since. Although the term is frequently used in textbooks, editorials and contemporary manuscripts its definition remains illusive ...
William W. Muir, Robert L. Hamlin
doaj   +1 more source

Stable, covalent attachment of laminin to microposts improves the contractility of mouse neonatal cardiomyocytes. [PDF]

, 2014
The mechanical output of contracting cardiomyocytes, the muscle cells of the heart, relates to healthy and disease states of the heart. Culturing cardiomyocytes on arrays of elastomeric microposts can enable inexpensive and high-throughput studies of ...
Ashley, Euan A, Pruitt, Beth L, Ribeiro, Alexandre JS, Zaleta-Rivera, Kathia   +3 more
core   +2 more sources

Defective Autophagy in Vascular Smooth Muscle Cells Alters Vascular Reactivity of the Mouse Femoral Artery

Frontiers in Physiology, 2020
Autophagy is an important cellular survival process that enables degradation and recycling of defective organelles and proteins to maintain cellular homeostasis.
Dorien G. De Munck, Sofie De Moudt, Lynn Roth, Guido R. Y. De Meyer, Wim Martinet, Paul Fransen   +5 more
doaj   +1 more source

Platelet Contractile Proteins [PDF]

Thrombosis and Haemostasis, 1977
Platelets contain a high concentration of the contractile proteins actin and myosin. The properties of these proteins are generally similar to their counterparts in muscle, suggesting that the platelet actin and myosin can generate contractile force.
openaire   +3 more sources

Phosphatidylinositol-3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising new target for the treatment of endometriosis-associated fibrosis

Gynecology and Minimally Invasive Therapy, 2014
Objective: To assess the involvement of phosphatidylinositol-3 kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) on the extracellular matrix contractility of endometriotic cells.
Wakana Abe, Kaei Nasu, Akitoshi Tsuno, Yukie Kawano, Hisashi Narahara   +4 more
doaj   +1 more source

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]

, 2017
The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C, Kaylan, Kerim B, Leckband, Deborah E, Underhill, Gregory H   +3 more
core   +1 more source