Results 21 to 30 of about 248,671 (308)

A novel method to extend viability and functionality of living heart slices

Frontiers in Cardiovascular Medicine, 2023
Living heart slices have recently emerged as a powerful experimental model for fundamental cardiac research. By retaining the structure and function of the native myocardium while maintaining the simplicity of cell culture models, heart slices can be ...
Abigail J. Ross, Iva Krumova, Berfin Tunc, Qin Wu, Qin Wu, Changhao Wu, Patrizia Camelliti   +6 more
doaj   +1 more source

What every ICU clinician needs to know about the cardiovascular effects caused by abdominal hypertension [PDF]

, 2015
The effects of increased intra-abdominal pressure (IAP) on cardiovascular function are well recognized and include a combined negative effect on preload, afterload and contractility.
De Keulenaer, Bart L, De Waele, Jan, Malbrain, Manu LNG   +2 more
core   +1 more source

Phenotyping of Mice with Heart Specific Overexpression of A2A-Adenosine Receptors: Evidence for Cardioprotective Effects of A2A-Adenosine Receptors

Frontiers in Pharmacology, 2018
Background: Adenosine can be produced in the heart and acts on cardiac adenosine receptors. One of these receptors is the A2A-adenosine receptor (A2A-AR).Methods and Results: To better understand its role in cardiac function, we generated and ...
Peter Boknik, Katharina Drzewiecki, John Eskandar, Ulrich Gergs, Stephanie Grote-Wessels, Larissa Fabritz, Paulus Kirchhof, Frank U. Müller, Frank Stümpel, Wilhelm Schmitz, Norbert Zimmermann, Uwe Kirchhefer, Joachim Neumann   +12 more
doaj   +1 more source

Long Prehensile Protrusions Can Facilitate Cancer Cell Invasion through the Basement Membrane

Cells, 2023
A basic process in cancer is the breaching of basement-membrane barriers to permit tissue invasion. Cancer cells can use proteases and physical mechanisms to produce initial holes in basement membranes, but how cells squeeze through this barrier into ...
Shayan S. Nazari, Andrew D. Doyle, Christopher K. E. Bleck, Kenneth M. Yamada   +3 more
doaj   +1 more source

Fascia Is Able to Actively Contract and May Thereby Influence Musculoskeletal Dynamics: A Histochemical and Mechanographic Investigation

Frontiers in Physiology, 2019
Fascial tissues form a ubiquitous network throughout the whole body, which is usually regarded as a passive contributor to biomechanical behavior. We aimed to answer the question, whether fascia may possess the capacity for cellular contraction which, in
Robert Schleip, Robert Schleip, Robert Schleip, Giulio Gabbiani, Jan Wilke, Ian Naylor, Boris Hinz, Adjo Zorn, Heike Jäger, Rainer Breul, Stephanie Schreiner, Werner Klingler, Werner Klingler   +12 more
doaj   +1 more source

Child’s heart development and contractility from prenatal to postnatal period

Российский кардиологический журнал, 2022
This literature review analyzes current data on the main stages of child’s heart contractility development from prenatal to postnatal period. The presented information will expand the conventional ideas on the age-related cardiovascular physiology in ...
E. N. Pavlyukova, M. V. Kolosova, A. I. Unasheva, G. V. Neklyudova, R. S. Karpov   +4 more
doaj   +1 more source

Regulation of pancreatic cancer aggressiveness by stromal stiffening [PDF]

, 2016
No abstract ...
A Neesse, AD Rhim, BC Özdemir, H Laklai, I Barbieri, JJ Lee, JK Mouw, JM Bailey, Michael F Olson, Nicola Rath, P Bailey, SR Hingorani, SR Hingorani, V Sanz-Moreno   +13 more
core   +1 more source

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Pigment Epithelium‐Derived Factor (PEDF) Improves Ischemic Cardiac Functional Reserve Through Decreasing Hypoxic Cardiomyocyte Contractility Through PEDF Receptor (PEDF‐R)

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundPigment epithelium‐derived factor (PEDF), which belongs to the noninhibitory serpin family, has shown the ability to stimulate several physiological processes, such as antiangiogenesis, anti‐inflammation, and antioxidation. In the present study,
Peng Lu, Yi‐Qian Zhang, Hao Zhang, Yu‐Feng Li, Xiao‐Yu Wang, Hao Xu, Zhi‐Wei Liu, Lei Li, Hong‐Yan Dong, Zhong‐Ming Zhang   +9 more
doaj   +1 more source

AI-Based Estimation of End-Systolic Elastance From Arm-Pressure and Systolic Time Intervals

Frontiers in Artificial Intelligence, 2021
Left ventricular end-systolic elastance (Ees) is a major determinant of cardiac systolic function and ventricular-arterial interaction. Previous methods for the Ees estimation require the use of the echocardiographic ejection fraction (EF).
Vasiliki Bikia, Dionysios Adamopoulos, Stamatia Pagoulatou, Georgios Rovas, Nikolaos Stergiopulos   +4 more
doaj   +1 more source