Results 101 to 110 of about 3,336,375 (342)

Accelerated optimization in deep learning with a proportional-integral-derivative controller

Nature Communications
High-performance optimization algorithms are essential in deep learning. However, understanding the behavior of optimization (i.e., learning process) remains challenging due to the instability and weak interpretability of the algorithms.
Song Chen, Jiaxu Liu, Pengkai Wang, Chao Xu, Shengze Cai, Jian Chu   +5 more
doaj   +1 more source

Distributed Dynamic Reference Governor for Constrained Semi-Autonomous Robotic Swarms with Communication Delays and Experimental Verification

SICE Journal of Control, Measurement, and System Integration, 2019
This paper investigates constrained semi-autonomous robotic swarms in the presence of inter-robot communication delays. The objective is that all robots converge to the optimal point related to the reference given by a human operator without violating ...
Aditya Wildan Farras, Takeshi Hatanaka, Tam W. Nguyen, Riku Funada, Junya Yamauchi, Masayuki Fujita   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Chemical research projects office functions accomplishments programs [PDF]

Basic and applied research in the fields of polymer chemistry, polymeric composites, chemical engineering, and biophysical chemistry is summarized.
Heimbuch, A. H., Parker, J. A.
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Resident research associateships. Postdoctoral and senior research awards: Opportunities for research at the Jet Propulsion Laboratory [PDF]

Opportunities for research as part of NASA-sponsored programs at the JPL cover: Earth and space sciences; systems; telecommunications science and engineering; control and energy conversion; applied mechanics; information systems; and observational ...

core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A modified CNN-IDS model for enhancing the efficacy of intrusion detection system

Measurement: Sensors
As the security of computer networks in enterprises worldwide is dependent on the proper functioning of intrusion detection systems (IDSs) and intrusion prevention systems (IPSs), this effectiveness of both of them is of utmost priority.
Ruqaya Abdulhasan Abed, Ekhlas Kadhum Hamza, Amjad J. Humaidi   +2 more
doaj   +1 more source

Temperature and Flow Decoupling Control for Air Heater Systems [PDF]

Journal of Electrical and Electronics Engineering, 2014
In this paper it is presented an optimized practical solution for controlling the temperature and flow of a multivariable process. The solution is based on software architecture that solves the technical problem of coupling between the two parameters ...
SOPONARIU Alexandru, LUPU Ciprian
doaj  

Advanced technologies for Mission Control Centers [PDF]

Advance technologies for Mission Control Centers are presented in the form of the viewgraphs. The following subject areas are covered: technology needs; current technology efforts at GSFC (human-machine interface development, object oriented software ...
Dalton, John T., Hughes, Peter M.
core   +1 more source