Results 101 to 110 of about 806,495 (313)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
V-Model Role Engineering [PDF]
The paper focuses on role engineering which is an important topic in the development of access control system, particularly when considering Role Based Access Control – RBAC models.
Radu CONSTANTINESCU
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International Conference on Industry, Engineering, and Management Systems 2025
Published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, November 2025. 2025 IEMS Officers: Gamal Weheba (Conference Chair); Hesham Mahgoub (Program Chair); Dalia Mahgoub (Technical Director); Ed Sawan ...
International Conference on Industry, Engineering, and Management Systems
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A conceptual system design and managerial complexity competency model [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Complex adaptive systems are usually difficult to design and control.
Amaechi, Austin Oguejiofor
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, 2011 Time delay control (TDC) for non-linear systems has rapidly drawn attention as a result of its unusually robust performance and yet its extraordinarily compact form. In many real applications, TDC has been implemented digitally and the time delay, λ, was
Stefanov, D. +5 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Architecting Joint Command and Control System of Systems Capability Certifications [PDF]
, 2007 Command, Control, Communications, Computers, and Intelligence (C4I) systems, each originally designed to address a single warfighting function, have been assembled into an interdependent C4I System of Systems (SoS).
Patel, Jaykant +13 more
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Supervisory control of multilevel discrete-event systems with a bus structure
, 2019 High-tech systems often contain a few components with many dependencies across the system, acting as system-level integrating components. In a hierarchical system decomposition, such so-called bus components tend to be placed in the top node.
van de Mortel - Fronczak, Asia +7 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source