Results 181 to 190 of about 17,739,623 (305)

Conditional or unconditional logistic regression for frequency matched case-control design? [PDF]

Stat Med, 2022
Wan F.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Quantum Control Design by Lyapunov Trajectory Tracking and Optimal Control. [PDF]

Entropy (Basel)
Yang H, Yu G, Ivanov IG.
europepmc   +1 more source

Investigation of the Optimum Baseline Blood Pressure for Spinal Anesthesia to Guide Vasopressor Management for Elective Cesarean Delivery: A Case-Control Design. [PDF]

Cureus, 2023
Kovacheva VP, Armero W, Zhou G, Bishop D, Dyer R, Carvalho B.   +5 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Time-Course Analysis of Cognitive Benefits Following Self-Stretching Using a Self-Control Design: Evidence from Stroop, N-Back, and Memory Tasks. [PDF]

Brain Sci
Park SY, Park SY, Park SY, Oh S.
europepmc   +1 more source

Effectiveness of COVID-19 vaccines against hospitalisation in Latin America during three pandemic waves, 2021-2022: a test-negative case-control design. [PDF]

Lancet Reg Health Am, 2023
Nogareda F, Regan AK, Couto P, Fowlkes AL, Gharpure R, Loayza S, Leite JA, Rodríguez A, Vicari A, Azziz-Baumgartner E, Salas D, REVELAC-i Working Group.   +11 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The effect of parental enhancing program with mobile application on parental stress and competence among Thai adolescent postpartum women: A quasi-experimental matched control design. [PDF]

PLoS One
Kleebpan S, Apartsakun P, Chaiyanusak P, Kitson-Reynolds E.   +3 more
europepmc   +1 more source

Stable and Fast Planar Jumping Control Design for a Compliant One-Legged Robot. [PDF]

Micromachines (Basel), 2022
Luo G, Du R, Song S, Yuan H, Huang Z, Zhou H, Gu J.   +6 more
europepmc   +1 more source