Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Vertical Shaft Drilling Rig Frequency Conversion Electronic Control Design and Its Energy Saving and Noise Reduction Effect Analysis. [PDF]
ACS OmegaTian G +5 more
europepmc +1 more source
Evaluating real-world COVID-19 vaccine effectiveness using a test-negative case-control design. [PDF]
J Comp Eff Res, 2022 Reynolds MW +8 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Event-Triggered Secure Control Design Against False Data Injection Attacks via Lyapunov-Based Neural Networks. [PDF]
Sensors (Basel)Kutlucan NK, Ucun L, Dasdemir J.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
A linear matric inequality based multi-loop PI control design for coupled multivariable liquid level system. [PDF]
Sci RepMahapatro SR, Roy C, Patel R, Das S.
europepmc +1 more source
Biomarker evaluation under imperfect nested case-control design. [PDF]
Stat Med, 2021 Wang X, Zheng Y, Jensen MK, He Z, Cai T.
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Creating a prediction model for invasive candidiasis in the intensive care unit using a case control design: a European multicentre approach. [PDF]
BMC Infect DisBenders PMB +5 more
europepmc +1 more source