Vertical Shaft Drilling Rig Frequency Conversion Electronic Control Design and Its Energy Saving and Noise Reduction Effect Analysis. [PDF]
ACS OmegaTian G +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Quantum Control Design by Lyapunov Trajectory Tracking and Optimal Control. [PDF]
Entropy (Basel)Yang H, Yu G, Ivanov IG.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Event-Triggered Secure Control Design Against False Data Injection Attacks via Lyapunov-Based Neural Networks. [PDF]
Sensors (Basel)Kutlucan NK, Ucun L, Dasdemir J.
europepmc +1 more source
Outcomes of kidney transplantation in patients with congenital anomalies of the kidney and urinary tract: a propensity-score-matched analysis with case-control design. [PDF]
Turk J Med Sci, 2023 Oto ÖA +11 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
A linear matric inequality based multi-loop PI control design for coupled multivariable liquid level system. [PDF]
Sci RepMahapatro SR, Roy C, Patel R, Das S.
europepmc +1 more source
Robust Optimal Control Design for Performance Enhancement of PWM Voltage Source Inverter. [PDF]
Micromachines (Basel), 2022 Chang EC +7 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source