Results 101 to 110 of about 6,305 (264)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

NON-LINEAR STATE SPACE MODEL AND CONTROL STRATEGY FOR PEM FUEL CELL SYSTEMS

Dyna, 2011
Este artículo presenta un modelo no lineal en el espacio de estado y un sistema de control lineal para una celda de combustible de Membrana de Intercambio Protónico.
RICHARD RIOS, CARLOS RAMOS, JAIRO ESPINOSA   +2 more
doaj  

Dinámica no lineal y control en Ecosistemas

, 2002
Resumen de Tesis Doctoral. Director: Ricard V. Solé. Centro: Universitat Politècnica de Catalunya. Universitat de Lleida. Fecha de lectura: 1 de Febrero 2002.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dinámica de un convertidor boost con inclusión de resistencias parásitas controlado con ZAD

Revista Científica de Ingeniería Energética, 2016
Como dispositivos electrónicos conmutados podemos destacar los convertidores elevador (boost) y reductor (buck), cada uno con su respectiva configuración y aplicaciones en electrónica de potencia.
Fredy Edimer Hoyos Velasco, Simeón Casanova Trujillo, Darío Del Cristo Vergara Pérez   +2 more
doaj  

Control no lineal del sistema Twin Rotor

, 2017
El Twin Rotor MIMO System és un sistema mecànic amb múltiples entrades i múltiples sortides assimilable a un helicòpter, però d’escala més reduïda. Una diferència destacable entre el Twin Rotor MIMO System i una maqueta d’helicòpter és que les forces aerodinàmiques no varien segons l’angle d’atac de les pales de les hèlixs sinó segons la velocitat ...
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Desarrollo del vehículo eléctrico tipo transportador personal

Perspectivas, 2019
El artículo presenta la construcción de un vehículo eléctrico tipo Segway de dos ruedas, a partir del diseño de cada una de sus partes y la aplicación de la ingeniería inversa, para su desarrollo en Ecuador.
Víctor Velasco-Ulco, Alexandra Chuquitarco-Aguayo, Edilberto Antonio Llanes-Cedeño, Juan Carlos Rocha-Hoyos   +3 more
doaj