Results 251 to 260 of about 167,930,433 (313)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Effect of Various Root Canal Irrigation Techniques on Root Dentin Mechanical Properties: An In Vitro Study. [PDF]

Int J Dent
AbuMostafa A, Almarshad M, Alharith D, Alabdulkareem M, Alqahtani A, Alhawsawi B, Alamassi B.   +6 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Coacervates as bio-inspired intermediates for materials processing.

Chem Commun (Camb)
Graafsma C, Jaber MR, Monreal Santiago G, Kamperman M.   +3 more
europepmc   +1 more source

Beyond the Status Quo: Particulate Matter Standards in Oral Dosage Forms. [PDF]

J Xenobiot
Pandey G, Chavda H.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Next-Generation Biomaterials for Hard Tissue Regeneration: Balancing Biofunctionality, Biomimetic Mechanics, and Antimicrobial Resistance. [PDF]

Materials (Basel)
Fonseca D, Gil J.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Mechanical versus Electronic Infusion Systems in Subcutaneous Immunoglobulin Therapy: A Structured Literature Review of Infusion-Site Reactions and Device Performance. [PDF]

Med Devices (Auckl)
Majapuro-Hirvonen A, Rutland B, Bosshard J.   +2 more
europepmc   +1 more source

Evaluation of polyampholyte thin film hydrogels for the prevention of <i>Ralstonia pickettii</i> adhesion in microgravity. [PDF]

RSC Adv
Shea A, Oneida S, Waynant KV, Bernards MT.   +3 more
europepmc   +1 more source