Results 61 to 70 of about 4,087,241 (316)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Finite‐time dissipative control for time‐delay Markov jump systems with conic‐type non‐linearities under guaranteed cost controller and quantiser

IET Control Theory & Applications, 2021
For a class of conic‐type non‐linear time‐delay Markov jump systems, the asynchronous dissipative output feedback controller based on the guaranteed cost control and quantiser is designed in this study. In real applications, the system and the controller
Xiang Zhang, Yanyan Yin, Hai Wang, Shuping He   +3 more
doaj   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

The sliding mode control approach design for nonholonomic mobile robots based on non‐negative piecewise predefined‐time control law

IET Control Theory & Applications, 2021
In this paper, a novel trajectory tracking control method of nonholonomic mobile robots based on the non‐negative piecewise predefined‐time theorem is proposed.
Lixiong Lin, Peixin Wu, Bingwei He, Yanjie Chen, Jiachun Zheng, Xiafu Peng   +5 more
doaj   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

On bipartite consensus of linear MASs with input saturation over directed signed graphs: Fully distributed adaptive approach

IET Control Theory & Applications, 2021
This paper studies the bipartite consensus problem with input saturation for general linear represents multi‐agent systems (MASs) with signed digraphs.
Xiaoya Nan, Yuezu Lv, Zhisheng Duan
doaj   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Computing frequency response of non‐parametric uncertainty model of MIMO systems using υ‐gap metric optimization

IET Control Theory & Applications, 2021
This paper presents the computation of the non‐parametric uncertainty model for multi input multi output (MIMO) systems, which is described by normalized coprime factors (NCF) using the frequency response data of the system.
Seyed Masoud Tabibian, Mohammad Ataei, Hamid Reza Koofigar   +2 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Separation principle for discrete‐time quasi‐one‐sided Lipschitz nonlinear systems

IET Control Theory & Applications, 2021
This paper is concerned with output stabilisation for a class of discrete‐time quasi‐one‐sided Lipschitz nonlinear systems. Firstly, an observer is designed for estimating the state of the systems in terms of quasi‐one‐sided Lipschitz condition and ...
Wenqiang Dong, Guang‐Da Hu, Yuhao Cong
doaj   +1 more source