Results 71 to 80 of about 2,605,132 (291)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Hierarchical speed control for autonomous electric vehicle through deep reinforcement learning and robust control

IET Control Theory & Applications, 2022
For the speed control system of autonomous electric vehicle (AEV), challenge happens with how to determine an appropriate driving speed to satisfy the dynamic environment while resisting uncertainty and disturbance.
Guangfei Xu, Xiangkun He, Meizhou Chen, Hequan Miao, Huanxiao Pang, Jian Wu, Peisong Diao, Wenjun Wang   +7 more
doaj   +1 more source

A new solution approach to polynomial LPV system analysis and synthesis [PDF]

, 2004
Based on sum-of-squares (SOS) decomposition, we propose a new solution approach for polynomial LPV system analysis and control synthesis problems.
Prajna, Stephen, Wu, Fen
core  

Microbial metabolism: optimal control of uptake versus synthesis [PDF]

, 2014
Microbes require several complex organic molecules for growth. A species may obtain a required factor by taking up molecules released by other species or by synthesizing the molecule.
Frank, Steven A.
core   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Gravity compensation and optimal control of actuated multibody system dynamics

IET Control Theory & Applications, 2022
This work investigates the gravity compensation topic, from a control perspective. The gravity could be levelled by a compensating mechanical system or in the control law, such as proportional derivative (PD) plus gravity, sliding mode control, or ...
Saeed Rafee Nekoo, José Ángel Acosta, Anibal Ollero   +2 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Composite control with observer for switched stochastic systems subject to multiple disturbances and input saturation

IET Control Theory & Applications, 2021
This paper investigates the composite hierarchical anti‐disturbance control problem for switched systems with saturating inputs, in which the multiple disturbances including normal‐bounded disturbances, white noises and nonlinear uncertainties are ...
Yunliang Wei, Guo‐Ping Liu, Jun Yang
doaj   +1 more source

Nonlinear control synthesis by convex optimization [PDF]

, 2004
A stability criterion for nonlinear systems, recently derived by the third author, can be viewed as a dual to Lyapunov's second theorem. The criterion is stated in terms of a function which can be interpreted as the stationary density of a substance that
Parrilo, Pablo A., Prajna, Stephen, Rantzer, Anders   +2 more
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source