Results 91 to 100 of about 162,137 (289)

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Driving pressure during general anesthesia for open abdominal surgery (DESIGNATION) : study protocol of a randomized clinical trial [PDF]

, 2020
Background Intraoperative driving pressure (Delta P) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (V-T) is kept constant, Delta P may change according to positive end-expiratory pressure (PEEP)-induced
Aarts, Leon P. H. J., Akkerman, Ronald D. L., Albersen, Juliette J. E., Aurilio, Caterina, Battaglini, Denise, Boer, Christa, Boom, Annemieke, Brouwer, Tammo, Buhre, Wolfgang F. F. A., Bulte, Carolina S. E., de Abreu, Marcelo Gama, de Boer, Hans D., De Korte-de Boer, Dianne J., Edward-Rutten, Gitara M., Godfried, Marc B., Helmerhorst, Hendrik J. F., Hemmes, Sabrine N. T., Hofland, Jan, Hol, Liselotte, Hol, Liselotte, Hollmann, Markus W., Hoogenboom, Hester, Houweling, Bernard M., Huhn, Ragnar, In 't Veld, Bastiaan A., Konijn, Wanda, Koopman-van Gemert, Ankie W. M. M., Kortekaas, Minke C., Neto, Ary Serpa, Nijbroek, Sunny G. L. H., Pelosi, Paolo, Preckel, Benedikt, Rad, Mandana, Sansone, Pasquale, Schultz, Marcus J., Stamkot, Andre, Stolker, Robert Jan, Struys, Michel, Ten Hoope, W., Thiel, Bram, Ubben, Johannes F. H., van der Zwan, Tim, Van Lier, Felix, Wrigge, Hermann, Zeillemaker-Hoekstra, Miriam, Zwijsen, Johannes H. M. J.   +45 more
core   +3 more sources

The efficacy and hemodynamic response to Dexmedetomidine as a hypotensive agent in posterior fixation surgery following traumatic spine injury

Journal of Anaesthesiology Clinical Pharmacology, 2014
Aim: This study was designed to evaluate the efficacy of dexmedetomidine (DEX) as a hypotensive agent in comparison to nitroglycerin (NTG) in posterior fixation surgery for traumatic spine injury.
Ramila H Jamaliya, Rajesh Chinnachamy, Jyotsna Maliwad, Varun P Deshmukh, Bharat J Shah, Indu A Chadha   +5 more
doaj   +1 more source

Controlled hypotension for spinal surgery [PDF]

European Spine Journal, 2004
Controlled, deliberate hypotension during anesthesia for major spinal surgery reduces intraoperative blood loss and transfusion requirement. Hypotension may be achieved with increased doses of volatile anesthetic agents or by continuous infusion of vasodilating drugs.
openaire   +2 more sources

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Investigation of robotics-assisted tilt-table therapy for early-stage rehabilitation in spinal cord injury [PDF]

, 2013
This article provides the outcome of an investigation of robotics-assisted tilt-table therapy for early-stage rehabilitation in spinal cord ...
Allan, David, Coupaud, Sylvie, Craven, Colm, Gollee, Henrik, Purcell, Mariel   +4 more
core   +1 more source

A Systematic Review and Meta-Analysis of Prophylactic Vasopressors for the Prevention of Peri-Intubation Hypotension

Diseases
Background/Objectives: Peri-intubation hypotension is a known complication of endotracheal intubation. In the hospital setting, peri-intubation hypotension has been shown to increase hospital mortality and length of stay.
Hollie Saunders, Subekshya Khadka, Rabi Shrestha, Hassan Z. Baig, Scott A. Helgeson   +4 more
doaj   +1 more source

Mitral Transcatheter Edge‐to‐Edge Repair in Patients With Advanced Heart Failure: A Single‐Center Experience and Insights Into Anatomical and Clinical Determinants of Procedural Complexity

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Advanced heart failure (HF) remains a clinical challenge, and mitral transcatheter edge‐to‐edge repair (M‐TEER) has emerged as a potential bridging strategy. Aims To describe the clinical outcomes of M‐TEER in a single‐center cohort of patients with advanced HF and to identify anatomical and clinical features potentially associated ...
Pedro Castilhos de Freitas Crivelaro, Laura Hastenteufel, Guilherme Pinheiro Machado, Felipe Fuchs, Antonio Pinotti, Marco Vugman Wainstein, Nadine Clausell, Lívia Adams Goldraich, Felipe Homem Valle   +8 more
wiley   +1 more source

Modulation of Neurally Mediated Vasodepression and Bradycardia by Electroacupuncture through Opioids in Nucleus Tractus Solitarius. [PDF]

, 2018
Stimulation of vagal afferent endings with intravenous phenylbiguanide (PBG) causes both bradycardia and vasodepression, simulating neurally mediated syncope.
Fu, Liang-Wu, Guo, Zhi-Ling, Longhurst, John C, Tjen-A-Looi, Stephanie C   +3 more
core   +3 more sources

Comparative study between magnesium sulphate and dexmedetomidine in controlled hypotension during functional endoscopic sinus surgery: a prospective randomized study

Ain Shams Journal of Anesthesiology, 2020
Background Functional endoscopic sinus surgery (FESS) has been proposed as a selected treatment used in patients with chronic sinusitis that have not responded to medical therapy.
Aya A. Bayoumy, Gihan S. Abo Zeid, Abeer M. El Deek, Marwa A. Elbeialy   +3 more
doaj   +1 more source